Human anti-beta1-adrenergic receptor (beta1AR) autoantibody ELISA Kit | ADRB1 elisa kit

Human anti-beta1-adrenergic receptor, beta1AR autoantibody ELISA Kit

Cat. Num. AAA705603

• Gene Names: ADRB1; RHR; B1AR; ADRB1R; BETA1AR
• Reactivity: Human
• Synonyms: anti-beta1-adrenergic receptor (beta1AR) autoantibody; Human anti-beta1-adrenergic receptor; beta1AR autoantibody ELISA Kit; Human anti-beta1-adrenergic receptor (beta1AR) autoantibody ELISA Kit; ADRB1 elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of human anti-beta1AR autoantibody. No significant cross-reactivity or interference between human anti-beta1AR autoantibody and analogues was observed.
• Sequence Length: 477

• Samples: Serum
• Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<10%. Three samples of known concentration were tested twenty times on one plate to assess.
• Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
• Preparation and Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ADRB1 elisa kit

Principle of the assay: This assay employs the qualitative enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with antigen. Samples are pipetted into the wells with anti-human immunoglobulin conjugated Horseradish Peroxidase (HRP). Any antibodies specific for the antigen present will bind to the pre-coated antigen. Following a wash to remove any unbound reagent, a substrate solution is added to the wells and color develops in proportion to the amount of human anti-beta1AR autoantibody bound in the initial step. The color development is stopped and the intensity of the color is measured.

NCBI and Uniprot Product Information

• NCBI GI #: 4557265
• NCBI GeneID: 153
• NCBI Accession #: NP_000675.1
• NCBI GenBank Nucleotide #: NM_000684.2
• UniProt Accession #: P08588; Q5T5Y4; Q9UKG7; Q9UKG8; B0LPE2
• Molecular Weight: 51,323 Da
• NCBI Official Full Name: beta-1 adrenergic receptor
• NCBI Official Synonym Full Names: adrenoceptor beta 1
• NCBI Official Symbol: ADRB1
• NCBI Official Synonym Symbols: RHR; B1AR; ADRB1R; BETA1AR
• NCBI Protein Information: beta-1 adrenergic receptor; beta-1 adrenoceptor; beta-1 adrenoreceptor; adrenergic, beta-1-, receptor
• UniProt Protein Name: Beta-1 adrenergic receptor
• Protein Family: Beta-1 adrenergic receptor
• UniProt Gene Name: ADRB1
• UniProt Synonym Gene Names: ADRB1R; B1AR; Beta-1 adrenoceptor
• UniProt Entry Name: ADRB1_HUMAN

NCBI Description

The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Mediates Ras activation through G(s)-alpha- and cAMP-mediated signaling.1 PublicationManual assertion based on experiment in:Ref.6