IL-33(untagged) Active Protein
IL-33, Recombinant, Human(untagged) (Interleukin-33, IL-1F11, NF-HEV)
Purity
Highly Purified>95% (SDS-PAGE)
Synonyms
IL-33(untagged); IL-33; Recombinant; Human(untagged) (Interleukin-33; IL-1F11; NF-HEV); IL-33(untagged) active protein
Host
Human, E Coli
Specificity
Binds to human ST2.
Purity/Purification
Highly Purified
>95% (SDS-PAGE)
>95% (SDS-PAGE)
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Sequence
Human IL-33 (aa 112-270) is untagged.
Biological Activity
Activates human ST2-dependent NF-kappaB pathway. Does not activate mouse ST2-dependent NF-kappaB.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Stable for at least 6 months after receipt when stored at -20 degree C.
Long-term Storage: -20 degree C
Stable for at least 6 months after receipt when stored at -20 degree C.
Related Product Information for IL-33(untagged) active protein
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Product Categories/Family for IL-33(untagged) active protein
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Product Notes
The IL-33(untagged) (Catalog #AAA638208) is an Active Protein produced from Human, E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Human IL-33 (aa 112-270) is untagged. It is sometimes possible for the material contained within the vial of "IL-33(untagged), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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