T-Cell Surface Protein Tactile Active Protein | Cd96 active protein

Recombinant Mouse T-Cell Surface Protein Tactile Protein

Cat. Num. AAA2556761

• Gene Names: Cd96; Tactile; 1700109I12Rik
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: T-Cell Surface Protein Tactile; Recombinant Mouse T-Cell Surface Protein Tactile Protein; T-cell surface protein tactile; Cell surface antigen CD96; T cell-activated increased late expression protein; CD96; Cd96 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Length: 602

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Met 1-Met 536
• Fusion Tag: C-6His
• Activity: 1. Measured by its binding ability in a functional ELISA. 2. Immobilized recombinant Mouse CD96 at 10 mug/ml (100 mul/well) can bind mouse PVR with a linear range of 6.4-160 ng/ml.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for Cd96 active protein

Protein Construction: Recombinant Mouse T-cell Surface Protein Tactile is produced by our Mammalian expression system and the target gene encoding Val22-Met536 is expressed with a 6His tag at the C-terminus.

Background: The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. The CD155 ligand CD96 is a member of the Ig superfamily. It's a immunoglobulin-like protein tentatively allocated to the repertoire of human NK receptors. NK cells recognize poliovirus receptor (PVR), anectins and nectin-like protein family member serve to mediate cell-cell adhesion, cell migration, with the presence of an additional receptor, CD96. CD96 promotes NK cell adhesion to target cells expressing PVR, stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells.

NCBI and Uniprot Product Information

• NCBI GI #: 160333634
• NCBI GeneID: 84544
• NCBI Accession #: NP_115854.2
• NCBI GenBank Nucleotide #: NM_032465.2
• UniProt Accession #: Q3U0X8; Q7TMW0; Q8C9U6; Q99M67
• Molecular Weight: Molecular Mass: 57.6kDa; Actual Protein Molecular Mass: 125kDa
• NCBI Official Full Name: T-cell surface protein tactile
• NCBI Official Synonym Full Names: CD96 antigen
• NCBI Official Symbol: Cd96
• NCBI Official Synonym Symbols: Tactile; 1700109I12Rik
• NCBI Protein Information: T-cell surface protein tactile
• UniProt Protein Name: T-cell surface protein tactile
• Protein Family: T-cell surface protein tactile
• UniProt Gene Name: Cd96

Uniprot Description

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation ().