Low Affinity IgG Fc Receptor III Active Protein | Fcgr3 active protein

Recombinant Mouse Low Affinity IgG Fc Receptor III Protein

Cat. Num. AAA2556782

• Gene Names: Fcgr3; CD16
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Low Affinity IgG Fc Receptor III; Recombinant Mouse Low Affinity IgG Fc Receptor III Protein; Low affinity immunoglobulin gamma Fc region receptor III; Fcgr3; Fc gamma Receptor III; CD-antigen 16; CD16; FcRIII; IgG Fc receptor III; Fcgr3 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Length: 261

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Met 1-Thr 215
• Fusion Tag: C-6His
• Activity: Measured by its binding ability in a functional ELISA.Immobilized mouse FCGR3-His at 10 mug/ml (100 mul/well) can bind biotinylated human IgG1The EC50 of biotinylated human IgG1 is 0.12-0.28 mug/ml.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for Fcgr3 active protein

Protein Construction: Recombinant Mouse Low affinity IgG Fc receptor III is produced by our Mammalian expression system and the target gene encoding Ala31-Thr215 is expressed with a 6His tag at the C-terminus.

Background: Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting of immunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a variety of myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligand binding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependent cellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of type I/IIa/III hypersensitivity.

NCBI and Uniprot Product Information

• NCBI GI #: 119877
• NCBI GeneID: 14131
• UniProt Accession #: P08508
• Molecular Weight: Molecular Mass: 22.0kDa; Actual Protein Molecular Mass: 35-40kDa
• NCBI Official Full Name: Low affinity immunoglobulin gamma Fc region receptor III
• NCBI Official Synonym Full Names: Fc receptor, IgG, low affinity III
• NCBI Official Symbol: Fcgr3
• NCBI Official Synonym Symbols: CD16
• NCBI Protein Information: low affinity immunoglobulin gamma Fc region receptor III
• UniProt Protein Name: Low affinity immunoglobulin gamma Fc region receptor III
• Protein Family: Low affinity immunoglobulin gamma Fc region receptor
• UniProt Gene Name: Fcgr3
• UniProt Synonym Gene Names: IgG Fc receptor III; FcRIII

Uniprot Description

Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor which binds to IgG1, IgG2a and IgG2b (PubMed:17558411). Mediates neutrophil activation by IgG complexes redundantly with Fcgr4 (PubMed:18097064).