Intercellular Adhesion Molecule 2 Active Protein | Icam2 active protein

Recombinant Mouse Intercellular Adhesion Molecule 2 Protein

Cat. Num. AAA2556766

• Gene Names: Icam2; CD102; Ly-60; Icam-2
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Intercellular Adhesion Molecule 2; Recombinant Mouse Intercellular Adhesion Molecule 2 Protein; Intercellular adhesion molecule 2; Icam2; ICAM-2; Lymphocyte function-associated AG-1 counter-receptor; CD102; Icam-2; CD102 antigen; Icam2 active protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM Tris, 150mM NaCl, pH8.0.
• Sequence Length: 277

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Met 1-Gln 222
• Fusion Tag: C-Fc
• Activity: Measured by the ability of the immobilized protein to support the adhesion of PMA-stimulated HSB2 human peripheral blood acute lymphoblastic leukemia cells.When 5 x 10E4 cells/well are added to rmICAM1 coated plates (12.5 mug/mL with 100 muL/well), > 30% cells will adhere after 1 hour incubation at 37 degree C.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

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Related Product Information for Icam2 active protein

Protein Construction: Recombinant Mouse Intercellular adhesion molecule 2 is produced by our Mammalian expression system and the target gene encoding Lys23-Gln222 is expressed with a Fc tag at the C-terminus.

Background: ICAM-2 is a 55-65 kD transmembrane glycoprotein possessing 2 extracellular Ig domains, a single transmembrane domain, and a short 26-amino acid cytoplasmic domain. ICAM-2 is expressed on most leukocytes, and is strongly expressed on vascular endothelial cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc. Serum levels of ICAM-2 correlated significantly with the inflammatory and course sequences of trichinosis in mice and had a similar relation with blood eosinophilia. So, estimation of ICAM-2 serum levels may prove useful in identification of trichinosis recent infections, and in monitoring the prognosis and response to treatment.

NCBI and Uniprot Product Information

• NCBI GI #: 6754274
• NCBI GeneID: 15896
• NCBI Accession #: NP_034624.1
• NCBI GenBank Nucleotide #: NM_010494.2
• UniProt Accession #: P35330; Q9D8Q4
• Molecular Weight: Molecular Mass: 49.7kDa; Actual Protein Molecular Mass: 70-90kDa
• NCBI Official Full Name: intercellular adhesion molecule 2
• NCBI Official Synonym Full Names: intercellular adhesion molecule 2
• NCBI Official Symbol: Icam2
• NCBI Official Synonym Symbols: CD102; Ly-60; Icam-2
• NCBI Protein Information: intercellular adhesion molecule 2
• UniProt Protein Name: Intercellular adhesion molecule 2
• Protein Family: Intercellular adhesion molecule
• UniProt Gene Name: Icam2
• UniProt Synonym Gene Names: Icam-2; ICAM-2

Uniprot Description

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.