Neuron Specific Enolase Protein | ENO2 protein
Neuron Specific Enolase (NSE), Human Brain
Custom preparations, technical support, bulk quantities and aliquoting available.
Associated Tumor Types: Small-Cell Carcinoma Neuroendocrine Tumor Breast Cancer
According to current literature, NSE is a glycolytic enzyme that catalyzes the conversion of phosphoglycerate to phosphoenol pyruvate and is present in neurons, neuroendocrine cells, and amine precursor uptake and decarboxylation (APUD) cells.
Neuron-specific enolase (NSE) is a neuronal form of the glycolytic enzyme enolase, which was first found in extracts of brain tissue, and was later shown to be present in APUD (amine precursor uptake and decarboxylation) cells and neurons of the diffuse neuroendocrine system but not in other peripheral cells. NSE is a valuable tumor marker for cancers of neuroendocrine origin, especially for small-cell lung cancer and neuroblastoma.
Elevated concentrations are observed in patients with neuroblastoma, pancreatic islet cell carcinoma, medullary thyroid carcinoma, pheochromocytoma, and other neuroendocrine tumors as well as in certain benign conditions. NSE levels are frequently increased in patients with SCLC and infrequently in patients with non-SCLC. NSE has therefore been used to monitor disease progression and management in SCLC.
NCBI and Uniprot Product Information
NCBI Description
catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate; may play a role in glycolysis [RGD, Feb 2006]
Uniprot Description
ENO2: an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.
Protein type: Lyase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11
Chromosomal Location of Human Ortholog: 12p13
Cellular Component: extracellular space; photoreceptor inner segment; phosphopyruvate hydratase complex; plasma membrane; perikaryon; cytosol
Molecular Function: magnesium ion binding; phosphopyruvate hydratase activity
Biological Process: glycolysis; carbohydrate metabolic process; glucose metabolic process; pathogenesis; gluconeogenesis
Research Articles on ENO2
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Product Notes
The ENO2 eno2 (Catalog #AAA173164) is a Protein produced from Human Brain and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Neuron Specific Enolase, Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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