AGAP3 blocking peptide

AGAP3 Peptide - C-terminal region

Cat. Num. AAA3243012

• Gene Names: AGAP3; CRAG; AGAP-3; CENTG3; MRIP-1; cnt-g3
• Reactivity: Human
• Applications: Western Blot
• Synonyms: AGAP3; AGAP3 Peptide - C-terminal region; AGAP3 blocking peptide

• Reactivity: Human
• Form/Format: Lyophilized powder
• Sequence: Synthetic peptide located within the following region: LTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELH
• Sequence Length: 875

• Applicable Applications for AGAP3 blocking peptide: Western Blot (WB)
• Preparation and Storage: Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Related Product Information for AGAP3 blocking peptide

This is a synthetic peptide designed for use in combination with anti-AGAP3 Antibody, made

Target Description: AGAP3 is a GTPase-activating protein for the ADP ribosylation factor family Potential. GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway.

Product Categories/Family for AGAP3 blocking peptide

Peptide

NCBI and Uniprot Product Information

• NCBI GI #: 110227613
• NCBI GeneID: 116988
• NCBI Accession #: NP_114152
• NCBI GenBank Nucleotide #: NM_031946
• UniProt Accession #: Q96P47
• Molecular Weight: 96kDa
• NCBI Official Full Name: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform a
• NCBI Official Synonym Full Names: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
• NCBI Official Symbol: AGAP3
• NCBI Official Synonym Symbols: CRAG; AGAP-3; CENTG3; MRIP-1; cnt-g3
• NCBI Protein Information: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
• UniProt Protein Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
• Protein Family: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein
• UniProt Gene Name: AGAP3
• UniProt Synonym Gene Names: CENTG3; AGAP-3; CRAG; Cnt-g3; MRIP-1
• UniProt Entry Name: AGAP3_HUMAN

NCBI Description

This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]

Uniprot Description

CENTG3: a member of the centaurin family of ADP-ribosylation factor directed (ARF) GTPase-activating proteins (GAPs). Protective against the pathogenesis of polyglutamine diseases. Mediates the nuclear translocation of the CENTG3-polyQ complexes and the formation of promyelocytic leukemia (PML) protein-associated nuclear bodies in reactive oxygen species (ROS) signaling. Promotes the degradation of polyQ proteins at PML nuclear bodies through the ubiquitin-proteasome pathway. Knockdown by small interfering RNA in neuronal cells consistently blocked the nuclear translocation of polyQ and enhanced polyQ-mediated cell death. Three alternatively-spliced isoforms have been described.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: membrane; cytoplasm; nucleus

Molecular Function: GTPase activity; GTP binding; zinc ion binding; polyubiquitin binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein import into nucleus, translocation; small GTPase mediated signal transduction; positive regulation of GTPase activity