Testing Data
(RB1CC1 antibody at 1/2000 dilution interacts with recombinant RB1CC1 protein with a DsbA tag. Predicted band size: 40KDa. Observed band size: 40KDa.)
anti-Human RB1CC1 Antibody | anti-RB1CC1 antibody
RB1CC1 Antibody
WB: 1:100-1:2000
Testing Data
(RB1CC1 antibody at 1/2000 dilution interacts with recombinant RB1CC1 protein with a DsbA tag. Predicted band size: 40KDa. Observed band size: 40KDa.)
Testing Data
(RB1CC1 antibody at 1/2000 dilution interacts with recombinant RB1CC1 protein with a DsbA tag. Predicted band size: 40KDa. Observed band size: 40KDa.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Uniprot Description
Involved in autophagy (PubMed:21775823). Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1 (PubMed:23392225). Required for the formation of the autophagosome-like double-membrane structure that surrounds the Salmonella-containing vacuole (SCV) during S.typhimurium infection and subsequent xenophagy (). Involved in repair of DNA damage caused by ionizing radiation, which subsequently improves cell survival by decreasing apoptosis (). Inhibits PTK2/FAK1 and PTK2B/PYK2 kinase activity, affecting their downstream signaling pathways (PubMed:10769033, PubMed:12221124). Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111 (). Functions as a DNA-binding transcription factor (PubMed:12095676). Is a potent regulator of the RB1 pathway through induction of RB1 expression (PubMed:14533007). Plays a crucial role in muscular differentiation (PubMed:12163359). Plays an indispensable role in fetal hematopoiesis and in the regulation of neuronal homeostasis ().
Research Articles on RB1CC1
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Product Notes
The RB1CC1 rb1cc1 (Catalog #AAA850099) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The RB1CC1 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's RB1CC1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). ELISA: 1:5000-1:20000 WB: 1:100-1:2000. Researchers should empirically determine the suitability of the RB1CC1 rb1cc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RB1CC1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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