anti-Human PARP1 Antibody | anti-PARP1 antibody
PARP1 Antibody
Gene Names
PARP11; ARTD11; MIB006; C12orf6
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Protein G-Sepharose affinity purified.
Synonyms
PARP1; PARP1 Antibody; Rabbit polyclonal IgG to PARP1; anti-PARP1 antibody
Reactivity
Human
Purity/Purification
Protein G-Sepharose affinity purified.
Form/Format
Liquid
Sequence Length
338
Applicable Applications for anti-PARP1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes
ELISA: 1:5000-1:20000
WB: 1:5000-1:10000
WB: 1:5000-1:10000
Immunogen
Synthetic peptide corresponding to C-terminus amino acids of PARP1 human protein.
Preservative
0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
Cellular Localization
Nucleus
Preparation and Storage
Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.
Testing Data
(PARP antibody at 1/5000dilution interacts with 293T whole cell lysate 40ug/Lane. Predicted band size: 113KDa. Observed band size: 113KDa. Additional band size: 200KDa, 70KDa.)
Related Product Information for anti-PARP1 antibody
PARP (Poly (ADP-ribose) polymerase) is a 113 kDa nuclear protein which can exist as a homo-or hetero-dimer, and is strongly activated by DNA strand breaks. This protein acts as a molecular "nick sensor" and functions in base excision repair, poly(ADPribosyl)ation of acceptor proteins involved in chromatin architecture and DNA metabolism, and participates in protein modification to enhance or repress transcription. PARP is ribosylated by PARP2, and during apoptosis, ICE family members, such as caspase 3 and 7, cleave PARP to yield an 85 kDa and a 25 kDa fragment.
Product Categories/Family for anti-PARP1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
28,098 Da
NCBI Official Full Name
poly
NCBI Official Synonym Full Names
poly(ADP-ribose) polymerase family member 11
NCBI Official Symbol
PARP11
NCBI Official Synonym Symbols
ARTD11; MIB006; C12orf6
NCBI Protein Information
poly [ADP-ribose] polymerase 11
UniProt Protein Name
Poly [ADP-ribose] polymerase 11
Protein Family
UniProt Gene Name
PARP11
UniProt Synonym Gene Names
C12orf6; PARP-11; ARTD11
Uniprot Description
Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis (). In vitro, exhibits mono(ADP-ribosyl) transferase activity (PubMed:25673562).
