anti-Human CLNS1A Antibody | anti-CLNS1A antibody

CLNS1A Antibody

Cat. Num. AAA8514865

• Gene Names: CLNS1A; CLCI; ICln; CLNS1B
• Reactivity: Human
• Applications: Western Blot
• Purity: Immunogen affinity purified
• Synonyms: CLNS1A; CLNS1A Antibody; Methylosome subunit pICln; Chloride conductance regulatory protein ICln; I(Cln); Chloride channel; nucleotide sensitive 1A; Chloride ion current inducer protein; ClCI; Reticulocyte pICln; anti-CLNS1A antibody

• Reactivity: Human
• Specificity: CLNS1A Antibody detects endogenous levels of total CLNS1A
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 237

• Applicable Applications for anti-CLNS1A antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthesized peptide
• Preparation and Storage: Store at-20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from HuvEc cells, K562 cells, HeLa cells, HepG2 cells, A549 cells and Jurkat cells, using CLNS1A antibody.)

NCBI and Uniprot Product Information

• NCBI GI #: 4502891
• NCBI GeneID: 1207
• NCBI Accession #: NP_001284.1
• NCBI GenBank Nucleotide #: NM_001293.2
• UniProt Accession #: P54105; Q0VDK6; Q9NRD2; Q9NRD3; B2RCS9
• Molecular Weight: 37 KD
• NCBI Official Full Name: methylosome subunit pICln isoform a
• NCBI Official Synonym Full Names: chloride nucleotide-sensitive channel 1A
• NCBI Official Symbol: CLNS1A
• NCBI Official Synonym Symbols: CLCI; ICln; CLNS1B
• NCBI Protein Information: methylosome subunit pICln
• UniProt Protein Name: Methylosome subunit pICln
• UniProt Gene Name: CLNS1A
• UniProt Synonym Gene Names: CLCI; ICLN; I(Cln); ClCI

NCBI Description

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

Uniprot Description

Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.