Human Signal Peptide, CUB Domain, EGF Like 3 (SCUBE3) Antibody Pair Kit | SCUBE3 antibody pair kit

Human Signal Peptide, CUB Domain, EGF Like 3 (SCUBE3) Antibody Pair Kit (with Standard)

Cat. Num. AAA2104561

• Gene Names: SCUBE3; CEGF3
• Reactivity: Human
• Applications: ELISA, ELISA
• Synonyms: Signal Peptide; CUB Domain; EGF Like 3 (SCUBE3); Human Signal Peptide; EGF Like 3 (SCUBE3) Antibody Pair Kit (with Standard); CEGF3; CUB Domain And EGF-Like Repeat Containing 3; Signal peptide; CUB and EGF-like domain-containing protein 3; SCUBE3 antibody pair kit

• Reactivity: Human

• Applicable Applications for SCUBE3 antibody pair kit: ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
• Samples: Serum, Plasma, Tissue Homogenates, Cell Lysates, Cell Culture Supernates and Other Biological Fluids
• Detection Range: 31.2-2000ng/mL
• Standard: Recombinant SCUBE3 (Lyophilized, 1 vial-10ug)
• Capture Antibody: Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
• Detection Antibody: Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)
• Producte Usage: Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
• Antibody Support Pack: Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685

Product Categories/Family for SCUBE3 antibody pair kit

Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 37573960
• NCBI GeneID: 222663
• Molecular Weight: 111,099 Da
• NCBI Official Full Name: Signal peptide, CUB domain, EGF-like 3
• NCBI Official Synonym Full Names: signal peptide, CUB domain and EGF like domain containing 3
• NCBI Official Symbol: SCUBE3
• NCBI Official Synonym Symbols: CEGF3
• NCBI Protein Information: signal peptide, CUB and EGF-like domain-containing protein 3
• UniProt Protein Name: Signal peptide, CUB and EGF-like domain-containing protein 3
• Protein Family: Signal peptide, CUB and EGF-like domain-containing protein
• UniProt Gene Name: SCUBE3

NCBI Description

This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Uniprot Description

Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression.