Complement C7 Active Protein | C7 active protein

Complement C7 protein

Cat. Num. AAA537072

• Purity: > 98% pure
• Synonyms: Complement C7; Complement C7 protein; C& protein; C7 active protein

• Host: Human
• Purity/Purification: > 98% pure
• Form/Format: Supplied as a liquid in PBS, pH 7.2, no preservatives added. 0.2um filtered.
• Concentration: 1.04mg/ml (varies by lot)
• Sequence Length: 843

• Biohazard: Starting material teseted negative for HIV-I/II Plus O antibodies, HCV Antibodies, HBsAg, Hbc antibodies, HTLV-I/II, STS Antibodies, HCV by NAT, HIV by NAT and West Nile Virus.
• Functional Activity: 240 kU/mg
• Species: Human
• Protein Type: Native
• Biohazard Information: Donor samples were tested and found to be negative for HBsAg, HTLV-I/II, STS, and for antibodies to HCV, HIV-1 and HIV-II. Nonetheless caution should be used when handling this material as there is a margin of error in all tests.
• Biological Significance: Native human C7 is a naturally glycosylated protein composed of a single polypeptide chain of 92,400 Da. C7 is essential for formation of the membrane attack complex (MAC) and is activated non-proteolytically by binding to recently-formed C5b,C6 complexes at the cell membrane. Each pathway of complement activation generates proteolytic enzyme complexes (C3/C5 convertases) which are bound to the target surface.
• Preparation and Storage: Ships on dry ice. Upon receipt store at -70°C.

Related Product Information for C7 active protein

Purified Complement C7 protein isolated from human plasma

Product Categories/Family for C7 active protein

Immunology; Native Protein; Complements

NCBI and Uniprot Product Information

• NCBI GI #: 45580688
• NCBI GeneID: 730
• NCBI Accession #: NP_000578.2
• NCBI GenBank Nucleotide #: NM_000587.2
• UniProt Accession #: P10643; Q6P3T5; Q92489
• Molecular Weight: 92.4 kDa
• NCBI Official Full Name: complement component C7
• NCBI Official Synonym Full Names: complement component 7
• NCBI Official Symbol: C7
• NCBI Protein Information: complement component C7
• UniProt Protein Name: Complement component C7
• Protein Family: Complement component
• UniProt Gene Name: C7
• UniProt Entry Name: CO7_HUMAN

NCBI Description

C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008]

Uniprot Description

C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Biological Process: cellular sodium ion homeostasis; cytolysis; complement activation, alternative pathway; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 7 Deficiency