High Mobility Group Nucleosome Binding Domain Protein 3 Recombinant Protein | HMGN3 recombinant protein

Recombinant High Mobility Group Nucleosome Binding Domain Protein 3 (HMGN3)

Cat. Num. AAA2123326

• Applications: SDS-Page, Western Blot
• Purity: >90%
• Synonyms: High Mobility Group Nucleosome Binding Domain Protein 3; Recombinant High Mobility Group Nucleosome Binding Domain Protein 3 (HMGN3); PNAS-24; PNAS-25; TRIP7; Thyroid Hormone Receptor Interactor 7; Thyroid receptor-interacting protein 7; HMGN3 recombinant protein

• Host: E Coli
• Purity/Purification: >90%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Positions: Met1~Glu99
• Sequence Length: 95

• Applicable Applications for HMGN3 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Human
• Tag: N-terminal His Tag
• Subcellular Location: Secreted
• Isoelectric Point: 9.7
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for HMGN3 recombinant protein

Infection immunity

NCBI and Uniprot Product Information

• NCBI GI #: 318067959
• NCBI Accession #: NP_001188291.1
• NCBI GenBank Nucleotide #: NP_001188291.1
• UniProt Accession #: Q15651
• Molecular Weight: Predicted Molecular Mass: 14.4kDa; Accurate Molecular Mass: 17kDa
• NCBI Official Full Name: high mobility group nucleosome-binding domain-containing protein 3 isoform c
• UniProt Protein Name: High mobility group nucleosome-binding domain-containing protein 3
• Protein Family: High mobility group nucleosome-binding domain-containing protein
• UniProt Gene Name: HMGN3
• UniProt Synonym Gene Names: TRIP7; TR-interacting protein 7; TRIP-7
• UniProt Entry Name: HMGN3_HUMAN

Uniprot Description

HMGN3: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Belongs to the HMGN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 6q14.1

Cellular Component: cytoplasm; nucleoplasm