Rabbit anti-Human HMGN3 Polyclonal Antibody | anti-HMGN3 antibody

HMGN3 Antibody

Cat. Num. AAA1497075

• Gene Names: HMGN3; TRIP7; PNAS-24; PNAS-25
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: >95%, Protein G Purified
• Synonyms: HMGN3; Polyclonal Antibody; HMGN3 Antibody; High mobility group nucleosome-binding domain-containing protein 3; TRIP7; PNAS-24; Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP-7; anti-HMGN3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >95%, Protein G Purified
• Sequence Length: 95

• Applicable Applications for anti-HMGN3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: Non-conjugated
• Immunogen: Recombinant human High mobility group nucleosome-binding domain-containing protein 3 protein
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-138955 / sc-138956
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human prostate cancer using MBS1497075 at dilution 1:100)

Related Product Information for anti-HMGN3 antibody

Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 318067959
• NCBI GeneID: 9324
• NCBI Accession #: NP_001188291.1
• NCBI GenBank Nucleotide #: NM_001201362.1
• UniProt Accession #: Q15651; Q5HYD3; Q7RTT0; Q969M5; Q9BZT7; B2RD37
• Molecular Weight: 8,378 Da
• NCBI Official Full Name: high mobility group nucleosome-binding domain-containing protein 3 isoform c
• NCBI Official Synonym Full Names: high mobility group nucleosomal binding domain 3
• NCBI Official Symbol: HMGN3
• NCBI Official Synonym Symbols: TRIP7; PNAS-24; PNAS-25
• NCBI Protein Information: high mobility group nucleosome-binding domain-containing protein 3
• UniProt Protein Name: High mobility group nucleosome-binding domain-containing protein 3
• Protein Family: High mobility group nucleosome-binding domain-containing protein
• UniProt Gene Name: HMGN3
• UniProt Synonym Gene Names: TRIP7; TR-interacting protein 7; TRIP-7
• UniProt Entry Name: HMGN3_HUMAN

NCBI Description

The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016]

Uniprot Description

HMGN3: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Belongs to the HMGN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 6q14.1

Cellular Component: chromatin; cytoplasm; nucleoplasm

Molecular Function: nucleosomal DNA binding; thyroid hormone receptor binding

Biological Process: chromatin modification; positive regulation of transcription from RNA polymerase II promoter