HIP116A Blocking Peptide | HLTF blocking peptide

HIP116A Antibody (Center) Blocking Peptide

• Gene Names: HLTF; ZBU1; HLTF1; RNF80; HIP116; SNF2L3; HIP116A; SMARCA3
• Synonyms: HIP116A; HIP116A Antibody (Center) Blocking Peptide; Helicase-like transcription factor; 364-; 632-; DNA-binding protein/plasminogen activator inhibitor 1 regulator; HIP116; RING finger protein 80; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3; HLTF; RNF80; SMARCA3; SNF2L3; ZBU1; HLTF blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human HIP116A. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1009

• Cellular Location: Cytoplasm. Nucleus. Nucleus, nucleolus Nucleus, nucleoplasm. Note: Nuclear localization is stimulated by progesterone.
• Tissue Location: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HLTF blocking peptide

Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

NCBI and Uniprot Product Information

• NCBI GI #: 60390864
• NCBI GeneID: 6596
• UniProt Accession #: Q14527; Q14536; Q16051; Q7KYJ6; Q86YA5; Q92652; Q96KM9; D3DNH3
• Molecular Weight: 99,919 Da
• NCBI Official Full Name: Helicase-like transcription factor
• NCBI Official Synonym Full Names: helicase like transcription factor
• NCBI Official Symbol: HLTF
• NCBI Official Synonym Symbols: ZBU1; HLTF1; RNF80; HIP116; SNF2L3; HIP116A; SMARCA3
• NCBI Protein Information: helicase-like transcription factor
• UniProt Protein Name: Helicase-like transcription factor
• Protein Family: Helicase-like transcription factor
• UniProt Gene Name: HLTF
• UniProt Synonym Gene Names: HIP116A; RNF80; SMARCA3; SNF2L3; ZBU1
• UniProt Entry Name: HLTF_HUMAN

NCBI Description

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq, Jul 2008]

Uniprot Description

SMARCA3: an enzyme with apparent ATP-dependent DNA helicase activity. Belongs to the SNF2/RAD54 helicase family, RAD16 subfamily. Two alternatively spliced human isoforms have been described.

Protein type: Ligase; EC 3.6.1.-; Nucleolus; EC 3.6.4.-; EC 6.3.2.-; Ubiquitin conjugating system; Helicase; EC 6.3.2.19; DNA-binding; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 3q25.1-q26.1

Cellular Component: membrane; nucleoplasm; nucleus

Molecular Function: DNA binding; protein binding; ubiquitin protein ligase binding

Biological Process: regulation of transcription, DNA-dependent