Hairy and Enhancer of Split 2 Recombinant Protein | HES2 recombinant protein
Recombinant Human Hairy and Enhancer of Split 2
Gene Names
HES2; bHLHb40
Purity
Greater than 80.0% as determined by SDS-PAGE.
Synonyms
Hairy and Enhancer of Split 2; Recombinant Human Hairy and Enhancer of Split 2; HES2 Human; Hairy and Enhancer of Split 2 Human Recombinant; bHLHb40; hairy and enhancer of split 2; Class B basic helix-loop-helix protein 40; HES2; HES2 recombinant protein
Host
E Coli
Purity/Purification
Greater than 80.0% as determined by SDS-PAGE.
Form/Format
HES2 protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered clear solution.
Sterile Filtered clear solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMGLPRRA GDAAELRKSL KPLLEKRRRA RINQSLSQLK GLILPLLGRE NSNCSKLEKA DVLEMTVRFL QELPASSWPT AAPLPCDSYR EGYSACVARL ARVLPACRVL EPAVSARLLE HLWRRAASAT LDGGRAGDSS GPSAPAPAPA SAPEPASAPV PSPPSPPCGP GLWRPW
Sequence Length
173
Related Product Information for HES2 recombinant protein
Description: HES2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 196 amino acids (1-173 a.a.) and having a molecular mass of 20.9kDa.HES2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Introduction: Hairy and enhancer of split 2 (HES2) belongs to the HES family and comprised of one basic helix-loop-helix (bHLH) domain and one orange domain. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. Activation of Notch signaling pathway initiates activation of HES family genes throughout the interaction between Notch intracellular domain and RBPSUH (CSL). HES2 is expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
Introduction: Hairy and enhancer of split 2 (HES2) belongs to the HES family and comprised of one basic helix-loop-helix (bHLH) domain and one orange domain. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. Activation of Notch signaling pathway initiates activation of HES family genes throughout the interaction between Notch intracellular domain and RBPSUH (CSL). HES2 is expressed in placenta, pancreatic cancer, colon cancer with RER, cervical cancer, and in head and neck tumors.
Product Categories/Family for HES2 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
8,607 Da
NCBI Official Full Name
transcription factor HES-2
NCBI Official Synonym Full Names
hes family bHLH transcription factor 2
NCBI Official Symbol
HES2
NCBI Official Synonym Symbols
bHLHb40
NCBI Protein Information
transcription factor HES-2; class B basic helix-loop-helix protein 40; hairy and enhancer of split 2
UniProt Protein Name
Transcription factor HES-2
Protein Family
UniProt Gene Name
HES2
UniProt Synonym Gene Names
BHLHB40; bHLHb40
UniProt Entry Name
HES2_HUMAN
Uniprot Description
HES2: Transcriptional repressor of genes that require a bHLH protein for their transcription. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 1p36.31
Cellular Component: nucleus
Molecular Function: protein dimerization activity; double-stranded DNA binding; transcription factor binding
Biological Process: transcription, DNA-dependent; negative regulation of transcription, DNA-dependent
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Product Notes
The HES2 hes2 (Catalog #AAA146551) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: MGSSHHH HHH SSGLVPRGSH MGSMGL PRRA GDAAELRKSL KPLLEKRRRA RINQSLSQLK GLILPLLGRE NSNCSKLEKA DVLEMTVRFL QELPASSWPT AAPLPCDSYR EGYSACVARL ARVLPACRVL EPAVSARLLE HLWRRAASAT LDGGRAGDSS GPSAPAPAPA SAPEPASAPV PSPPSPPCGP GLWRPW. It is sometimes possible for the material contained within the vial of "Hairy and Enhancer of Split 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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