TGF beta 1 Active Protein | TGFB active protein

Recombinant Rat TGF beta 1 Protein

Cat. Num. AAA2553684

• Gene Names: Tgfb1; Tgfb
• Purity: >90% as determined by SDS-PAGE
• Synonyms: TGF beta 1; Recombinant Rat TGF beta 1 Protein; TGF-beta 1; TGFbeta; TGFB active protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Positions: Ala279-Ser390
• Sequence Length: 390

• Species: Rat
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method.
• Activity: Measured by its ability to inhibit cell proliferation of Mv-1-lu mink lung epithelial cells. The ED50 for this effect is 0.2-0.8 ng/mL.
• Preparation and Storage: Lyophilized proteins are stable for up to 12 months when stored at -20°C to -80°C; Reconsituted protein solution can be stored at 4°C to 8°C for 2-7 days. ; Aliquots of reconstituted samples are stable at <-20°C for 3 months.

Related Product Information for TGFB active protein

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-gamma, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.

NCBI and Uniprot Product Information

• NCBI GI #: 45239050
• NCBI GeneID: 59086
• Molecular Weight: Molecular Mass: 12.8 kDa; Actual Protein Mass: 12.8 kDa
• NCBI Official Full Name: TGF beta 1
• NCBI Official Synonym Full Names: transforming growth factor, beta 1
• NCBI Official Symbol: Tgfb1
• NCBI Official Synonym Symbols: Tgfb
• NCBI Protein Information: transforming growth factor beta-1 proprotein
• UniProt Protein Name: Transforming growth factor beta-1 proprotein
• UniProt Gene Name: Tgfb1
• UniProt Synonym Gene Names: LAP; TGF-beta-1

NCBI Description

binds the TGFbeta receptor; plays a role in regulation of cell growth and proliferation; induces synthesis of extracellular matrix proteins and may play a role in fibrosis [RGD, Feb 2006]

Uniprot Description

Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively.