Kallikrein-13 Active Protein | KLK13 active protein

Human CellExp Kallikrein-13, human recombinant

Cat. Num. AAA844269

• Gene Names: KLK13; KLKL4; KLK-L4
• Applications: SDS-Page
• Purity: >=95%
• Synonyms: Kallikrein-13; Human CellExp Kallikrein-13; human recombinant; KLK13; KLKL4; KLK-13; KLK13 active protein

• Host: HEK293 cells
• Purity/Purification: >=95%
• Form/Format: Lyophilized from 0.22 mum filtered solution in 20 mM MES, 150 mM NaCl, pH 6.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.; Appearance: Lyophilized
• Sequence Length: 277

• Applicable Applications for KLK13 active protein: SDS-PAGE
• Solubility/Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 ug/ml. Do not vortex. This solution can be stored at 2-8 degree C for up to 1 month. For extended storage, it is recommended to store at -20 degree C.
• Endotoxin Level: <1 EU/mug by LAL method
• Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is > 150 pmoles / min / ug.
• Results: Measured by its ability to cleave the fluorogenic peptide substrate Boc-VPR-AMC. The specific activity is > 150 pmoles / min / ug.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -20 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for KLK13 active protein

Background: Kallikrein-13 (KLK13) is also known as Kallikrein-like protein 4 (KLK-L4), is a secreted protein, belongs to the peptidase S1 family and Kallikrein subfamily. KLK-13 contains one peptidase S1 domain. KLK13 is mainly expressed in prostate, breast, testis and salivary gland. KLK13 may be involved in the pathogenesis and / or progression of breast and ovary cancers, and is regarded as a novel cancer biomarker. In addition, KLK13 interacts and forms complexes with several serum protease inhibitors, such as alpha2-macroglobulin, and its expression is regulated by steroid hormones.

Product Categories/Family for KLK13 active protein

Proteins and Enzymes; Human cell expressed recombinant proteinsProteins and Enzymes; Other Proteins & EnzymesProteins and Enzymes; Proteins and Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 11496281
• NCBI GeneID: 26085
• NCBI Accession #: NP_056411.1
• NCBI GenBank Nucleotide #: NM_015596.1
• UniProt Accession #: Q9UKR3; Q86VI8; Q9Y433; A7UNK6
• Molecular Weight: This protein is fused with 6×his tag at the C-terminus, and has a calculated MW of 28 kDa. The predicted N-terminus is Gly 18. DTT-reduced Protein migrates as 33-40 kDa in SDS-PAGE due to glycosylation.
• NCBI Official Full Name: kallikrein-13
• NCBI Official Synonym Full Names: kallikrein-related peptidase 13
• NCBI Official Symbol: KLK13
• NCBI Official Synonym Symbols: KLKL4; KLK-L4
• NCBI Protein Information: kallikrein-13
• UniProt Protein Name: Kallikrein-13
• Protein Family: Kallikrein
• UniProt Gene Name: KLK13
• UniProt Synonym Gene Names: KLKL4; KLK-L4
• UniProt Entry Name: KLK13_HUMAN

NCBI Description

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

KLK13: Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.21.-; Vesicle

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular space; cytoplasm; extracellular region; secretory granule

Molecular Function: protein binding; hydrolase activity; serine-type endopeptidase activity

Biological Process: protein processing; proteolysis