Dll4 active protein

Human CellExp DLL4, Mouse Recombinant

Cat. Num. AAA849791

• Gene Names: Dll4; Delta4
• Purity: >90% by SDS-PAGE
• Synonyms: DLL4; Human CellExp DLL4; Mouse Recombinant; Delta-like Protein 4; Delta 4; Dll4 active protein

• Host: HEK293 cells
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Liquid. 0.2 um-filtered solution in PBS

• Gene Source: Mouse
• Endotoxin: <1.0 EU per/ug
• Biological Activity: Measured by inhibition of adipogenesis of 3T3L-1 cells
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

Immunohistochemistry (IHC)

Related Product Information for Dll4 active protein

The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

Product Categories/Family for Dll4 active protein

Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins; Proteins; Enzymes; Human cell expressed recombinant proteins Cytokines; BAFFs; Cytokines & Growth Factors (A-Z); Proteins & Enzymes (A-Z); Signaling Pathways; TNF Signaling P

NCBI and Uniprot Product Information

• NCBI GI #: 244799228
• NCBI GeneID: 54485
• NCBI Accession #: NP_062327.2
• NCBI GenBank Nucleotide #: NM_019454.3
• UniProt Accession #: Q9JI71; Q9DBU9; Q9JHZ7
• Molecular Weight: 74,991 Da
• NCBI Official Full Name: delta-like protein 4
• NCBI Official Synonym Full Names: delta-like 4 (Drosophila)
• NCBI Official Symbol: Dll4
• NCBI Official Synonym Symbols: Delta4
• NCBI Protein Information: delta-like protein 4
• UniProt Protein Name: Delta-like protein 4
• Protein Family: Delta-like protein
• UniProt Gene Name: Dll4
• UniProt Synonym Gene Names: Delta4
• UniProt Entry Name: DLL4_MOUSE

Uniprot Description

DLL4: Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4. Binds to Notch-1 and Notch-4. Expressed in vascular endothelium.

Protein type: Cell development/differentiation; Membrane protein, integral

Cellular Component: integral to plasma membrane

Molecular Function: Notch binding; protein binding

Biological Process: angiogenesis; blood vessel remodeling; negative regulation of blood vessel endothelial cell migration; negative regulation of cell proliferation; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; patterning of blood vessels; positive regulation of Notch signaling pathway; regulation of neurogenesis; T cell differentiation