CD31/PECAM-1 active protein
Human CD31/PECAM-1
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Uniprot Description
Function: Induces susceptibility to atherosclerosis
By similarity. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). Ref.14 Ref.19 Ref.21
Subunit structure: Interacts with PTPN11; Tyr-713 is critical for PTPN11 recruitment. Forms a complex with BDKRB2 and GNAQ. Interacts with BDKRB2 and GNAQ. Ref.17 Ref.19 Ref.21
Subcellular location: Isoform Long: Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction. Note: Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Ref.19 Ref.21 Ref.25Isoform Delta15: Cell junction. Note: Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Ref.19 Ref.21 Ref.25
Tissue specificity: Expressed on platelets and leukocytes and is primarily concentrated at the borders between endothelial cells. Isoform Long predominates in all tissues examined. Isoform Delta12 is detected only in trachea. Isoform Delta14-15 is only detected in lung. Isoform Delta14 is detected in all tissues examined with the strongest expression in heart. Isoform Delta15 is expressed in brain, testis, ovary, cell surface of platelets, human umbilical vein endothelial cells (HUVECs), Jurkat T-cell leukemia, human erythroleukemia (HEL) and U-937 histiocytic lymphoma cell lines (at protein level). Ref.15 Ref.21
Domain: The Ig-like C2-type domains 2 and 3 contribute to formation of the complex with BDKRB2 and in regulation of its activity.
Post-translational modification: Phosphorylated on Ser and Tyr residues after cellular activation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation
By similarity. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation. Ref.13 Ref.18 Ref.21Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells. Ref.16 Ref.25
Sequence similarities: Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Research Articles on CD31/PECAM-1
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Product Notes
The CD31/PECAM-1 pecam1 (Catalog #AAA691690) is an Active Protein produced from HEK 293 Cells and is intended for research purposes only. The product is available for immediate purchase. The Human CD31/PECAM-1 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ENSFTINSVD MKSLPDWTVQ NGKNLTLQCF ADVSTTSHVK PQHQML FYKD DVLFYNISSM KSTESYFIPE VRIYDSGTYK CTVIVNNKEK T TAEYQLLVE GVPSPRVTLD KKEAIQGGIV RVNCSVPEEK APIHFTI EKL ELNEKMVKLK REKNSRDQNF VILEFPVEEQ DRVLSFRCQA RI ISGIHMQT SESTKSELVT VTESFSTPKF HISPTGMIME GAQLHIKC TI QVTHLAQEFP EIIIQKDKAI VAHNRHGNKA VYSVMAMVEH SGN YTCKVES SRISKVSSIV VNITELFSKP ELESSFTHLD QGERLNLSC S IPGAPPANFT IQKEDTIVSQ TQDFTKIASK SDSGTYICTA GIDK VVKKSN TVQIVVCEML SQPRISYDAQ FEVIKGQTIE VRCESISGTL PISYQLLKTS KVLENSTKNS NDPAVFKDNP TEDVEYQCVA DNCHS HAKML SEVLRVKVIA PVDEVQISIL SSKVVESGED IVLQCAVNEG SGPITYKFYR EKEGKPFYQM TSNATQAFWT KQKASKEQEG EYYCTA FNRA NHASSVPRSK ILTVRVILAP WK. It is sometimes possible for the material contained within the vial of "CD31/PECAM-1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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