Granzyme K Blocking Peptide | H85 blocking peptide

Granzyme K (H85) Peptide

Cat. Num. AAA3002575

• Applications: Blocking
• Purity: Synthetic peptide Granzyme K (H85). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: Granzyme K; Granzyme K (H85) Peptide; EC 3.4.21.-; Granzyme-3; NK-tryptase-2; NK-TRYP-2; Fragmentin-3; GZMK; TRYP2; H85 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002574 Granzyme K (H85) pAb.
• Purity/Purification: Synthetic peptide Granzyme K (H85). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 264

• Applicable Applications for H85 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for H85 blocking peptide

The granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs, granzyme A and B are processed and converted to their active forms by the lysosomal cysteine protease cathepsin C. Once cleaved, these active proteases target distinct substrates for proteolysis and, thereby, mediate apoptosis through two different pathways. Granzyme H localizes to cytoplasmic granules of cytolytic T lymphocytes and is important for target cell lysis in cell-mediated immune responses. Granzyme K (GMZK), also designated granzyme-3 or NK-tryptase-2 (NK-TRYP-2), contains one peptidase S1 domain. Granzyme K is a serine protease localizing to the granules of natural killer cells and cytotoxic T lymphocytes. It is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 4504235
• NCBI Accession #: NP_002095.1
• NCBI GenBank Nucleotide #: NP_002095.1
• UniProt Accession #: P49863
• NCBI Official Full Name: granzyme K
• UniProt Protein Name: Granzyme K
• Protein Family: Granzyme
• UniProt Gene Name: GZMK
• UniProt Synonym Gene Names: TRYP2; NK-Tryp-2
• UniProt Entry Name: GRAK_HUMAN

Uniprot Description

GZMK: this protein is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]

Protein type: EC 3.4.21.-; Protease; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: extracellular region

Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity

Biological Process: proteolysis