Guinea Pig Kynureninase (KYNU) ELISA Kit | KYNU elisa kit
Guinea pig Kynureninase (KYNU) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
enzyme involved in the biosynthesis of NAD cofactors from tryptophan [RGD, Feb 2006]
Uniprot Description
KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Hydrolase; EC 3.7.1.3; Amino Acid Metabolism - tryptophan
Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol
Molecular Function: protein homodimerization activity; kynureninase activity; pyridoxal phosphate binding
Biological Process: anthranilate metabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; quinolinate biosynthetic process; tryptophan catabolic process
Research Articles on KYNU
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Product Notes
The Guinea Pig KYNU kynu (Catalog #AAA2601608) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2601608 ELISA Kit recognizes Guinea Pig KYNU. It is sometimes possible for the material contained within the vial of "Kynureninase (KYNU), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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