Guinea Pig Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) ELISA Kit | HPRT1 elisa kit
Guinea pig Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.[provided by RefSeq, Jun 2009]
Uniprot Description
HPRT1: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS). LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT); also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Protein type: Nucleotide Metabolism - purine; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; EC 2.4.2.8; Cell development/differentiation
Chromosomal Location of Human Ortholog: Xq26.1
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; protein homodimerization activity; nucleotide binding; hypoxanthine phosphoribosyltransferase activity; magnesium ion binding
Biological Process: grooming behavior; lymphocyte proliferation; hypoxanthine metabolic process; IMP salvage; striatum development; GMP salvage; nucleobase, nucleoside and nucleotide metabolic process; dendrite morphogenesis; cytolysis; response to amphetamine; locomotory behavior; adenine salvage; purine nucleotide biosynthetic process; dopamine metabolic process; purine salvage; purine base metabolic process; cerebral cortex neuron differentiation; protein homotetramerization; GMP catabolic process; positive regulation of dopamine metabolic process; IMP metabolic process; hypoxanthine salvage; purine ribonucleoside salvage; guanine salvage; central nervous system neuron development
Disease: Kelley-seegmiller Syndrome; Lesch-nyhan Syndrome
Research Articles on HPRT1
Similar Products
Product Notes
The Guinea Pig HPRT1 hprt1 (Catalog #AAA7240826) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7240826 ELISA Kit recognizes Guinea Pig HPRT1. It is sometimes possible for the material contained within the vial of "Hypoxanthine-guanine phosphoribosyltransferase (HPRT1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
