Guinea Pig Calreticulin-3 (CALR3) ELISA Kit | CALR3 elisa kit
Guinea pig Calreticulin-3 (CALR3) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
Uniprot Description
calreticulin 3: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility. CALR3 capacity for calcium- binding may be absent or much lower than that of CALR. Defects in CALR3 are the cause of familial hypertrophic cardiomyopathy type 19 (CMH19). CMH19 is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the calreticulin family.
Protein type: Chaperone; Cancer Testis Antigen (CTA)
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component: endoplasmic reticulum lumen
Molecular Function: unfolded protein binding; calcium ion binding; carbohydrate binding
Biological Process: protein folding; spermatogenesis; cell differentiation
Disease: Cardiomyopathy, Familial Hypertrophic, 19
Research Articles on CALR3
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Product Notes
The Guinea Pig CALR3 calr3 (Catalog #AAA7227800) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7227800 ELISA Kit recognizes Guinea Pig CALR3. It is sometimes possible for the material contained within the vial of "Calreticulin-3 (CALR3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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