Western Blot (WB)
(CALR3 rabbit polyclonal antibody. Western Blot analysis of CALR3 expression in mouse lung.)
Rabbit anti-Human, Mouse CALR3 Polyclonal Antibody | anti-CALR3 antibody
CALR3 (Calreticulin 3, Calreticulin-3, Calreticulin-2, Calsperin, CRT2)
Serum
Serum
Western Blot (WB)
(CALR3 rabbit polyclonal antibody. Western Blot analysis of CALR3 expression in mouse lung.)
Western Blot (WB)
(CALR3 rabbit polyclonal antibody. Western Blot analysis of CALR3 expression in mouse lung.)
Immunoprecipitation (IP)
(Immunoprecipitation of CALR3 transfected lysate using CALR3 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with CALR3 mouse polyclonal antibody.)
Immunoprecipitation (IP)
(Immunoprecipitation of CALR3 transfected lysate using CALR3 rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with CALR3 mouse polyclonal antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]
Uniprot Description
Function: During spermatogenesis, may act as a lectin-independent chaperone for specific client proteins such as ADAM3. Required for sperm fertility
By similarity. CALR3 capacity for calcium-binding may be absent or much lower than that of CALR. Ref.1
Subunit structure: Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5
By similarity.
Subcellular location: Endoplasmic reticulum lumen Ref.1.
Tissue specificity: Testis specific. Ref.6
Domain: Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity
By similarity.The interaction with glycans occurs through a binding site in the globular lectin domain
By similarity.The zinc binding sites are localized to the N-domain
By similarity.
Involvement in disease: Cardiomyopathy, familial hypertrophic 19 (CMH19) [MIM:613875]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7
Sequence similarities: Belongs to the calreticulin family.
Research Articles on CALR3
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Product Notes
The CALR3 calr3 (Catalog #AAA648993) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CALR3 (Calreticulin 3, Calreticulin-3, Calreticulin-2, Calsperin, CRT2) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CALR3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Suitable for use in Western Blot and Immunoprecipitation. Researchers should empirically determine the suitability of the CALR3 calr3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MARALVQFWA ICMLRVALAT VYFQEEFLDG EHWRNRWLQS TNDSRFGHFR LSSGKFYGHK EKDKGLQTTQ NGRFYAISAR FKPFSNKGKT LVIQYTVKHE QKMDCGGGYI KVFPADIDQK NLNGKSQYYI MFGPDICGFD IKKVHVILHF KNKYHENKKL IRCKVDGFTH LYTLILRPDL SYDVKIDGQS IESGSIEYDW NLTSLKKETS PAESKDWEQT KDNKAQDWEK HFLDASTSKQ SDWNGDLDGD WPAPMLQKPP YQDGLKPEGI HKDVWLHRKM KNTDYLTQYD LSEFENIGAI GLELWQVRSG TIFDNFLITD DEEYADNFGK ATWGETKGPE REMDAIQAKE EMKKAREEEE EELLSGKINR HEHYFNQFHR RNEL. It is sometimes possible for the material contained within the vial of "CALR3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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