Transcription initiation factor IIB Recombinant Protein | TF2B recombinant protein
Recombinant Human Transcription initiation factor IIB
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]
Uniprot Description
GTF2B: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family.
Protein type: Acetyltransferase; Nuclear receptor co-regulator; Transcription factor
Chromosomal Location of Human Ortholog: 1p22.2
Cellular Component: nuclear body; nucleoplasm; nucleus; transcription factor TFIID complex
Molecular Function: protein binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding
Biological Process: positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcriptional preinitiation complex assembly