Transcription initiation factor IIB Recombinant Protein | TF2B recombinant protein

Recombinant Human Transcription initiation factor IIB

Cat. Num. AAA9420295

• Gene Names: GTF2B; TF2B; TFIIB
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Transcription initiation factor IIB; Recombinant Human Transcription initiation factor IIB; General transcription factor TFIIBS300-II; TF2B recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-316aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for TF2B recombinant protein

General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.

NCBI and Uniprot Product Information

• NCBI GI #: 4504193
• NCBI GeneID: 2959
• NCBI Accession #: NP_001505.1
• NCBI GenBank Nucleotide #: NM_001514.5
• UniProt Accession #: Q00403; Q5JS30; A8K1A7
• Molecular Weight: 50.8kD
• NCBI Official Full Name: transcription initiation factor IIB
• NCBI Official Synonym Full Names: general transcription factor IIB
• NCBI Official Symbol: GTF2B
• NCBI Official Synonym Symbols: TF2B; TFIIB
• NCBI Protein Information: transcription initiation factor IIB
• UniProt Protein Name: Transcription initiation factor IIB
• Protein Family: Transcription initiation factor
• UniProt Gene Name: GTF2B
• UniProt Synonym Gene Names: TF2B; TFIIB

NCBI Description

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. [provided by RefSeq, Jul 2008]

Uniprot Description

GTF2B: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II. Associates with TFIID-IIA (DA complex) to form TFIID-IIA- IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1. Interacts with Epstein-Barr virus EBNA2. Belongs to the TFIIB family.

Protein type: Acetyltransferase; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: nuclear body; nucleoplasm; nucleus; transcription factor TFIID complex

Molecular Function: protein binding; TATA-binding protein binding; thyroid hormone receptor binding; transcription factor binding

Biological Process: positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; snRNA transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcriptional preinitiation complex assembly