Testing Data
Progranulin Recombinant Protein | GRN recombinant protein
Human CellExp Progranulin, Rat Recombinant
Applications
SDS-Page
Purity
>=95%
Synonyms
Progranulin; Human CellExp Progranulin; Rat Recombinant; Proepithelin; PEPI; PC Cell-derived Growth Factor; GRN recombinant protein
Host
HEK 293 cells
Purity/Purification
>=95%
Form/Format
Lyophilized from 0.2 um-filtered solution in PBS.
Appearance: Lyophilized protein
Appearance: Lyophilized protein
Concentration
0.3 mg/ml (varies by lot)
Sequence
Signal peptide and rat Progranulin (aa 1-602) fused at the C-terminus to a DYKDDDDK-tag.
Sequence Length
602
Applicable Applications for GRN recombinant protein
SDS-PAGE; HPLC
Solubility/Reconstitution Instructions
Reconstitute in dH2O before use.
Endotoxin Level
<0.1 EU/mug purified protein
Handling
Centrifuge the vial prior to opening.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Testing Data
Testing Data
Related Product Information for GRN recombinant protein
Background: Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. Rat Recombinant Progranulin fused to DYKDDDDK at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified by standard chromatographic techniques, containing 602 amino acids and having a molecular mass of ~65.0 kDa.
Product Categories/Family for GRN recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~65.0 kDa
NCBI Official Full Name
granulins isoform a
NCBI Official Synonym Full Names
granulin
NCBI Official Symbol
Grn
NCBI Protein Information
granulins
UniProt Protein Name
Granulins
Protein Family
UniProt Gene Name
Grn
UniProt Entry Name
GRN_RAT
NCBI Description
plays a role in regulation of epithelial cell growth [RGD, Feb 2006]
Uniprot Description
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
Research Articles on GRN
Similar Products
Product Notes
The GRN grn (Catalog #AAA844889) is a Recombinant Protein produced from HEK 293 cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Progranulin can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE; HPLC. Researchers should empirically determine the suitability of the GRN grn for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Signal peptide and rat Progranuli n (aa 1-602) fused at the C-terminus to a DYKDDDDK-t ag. It is sometimes possible for the material contained within the vial of "Progranulin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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