Mouse Platelet glycoprotein VI ELISA Kit | Gp6 elisa kit

Mouse Platelet glycoprotein VI ELISA Kit

Cat. Num. AAA2882614

• Gene Names: Gp6; Gpvi; Gm469; 9830166G18Rik
• Reactivity: Mouse
• Synonyms: Platelet glycoprotein VI; Mouse Platelet glycoprotein VI ELISA Kit; GPVI; Glycoprotein 5; Gp6; Gp6 elisa kit

• Reactivity: Mouse
• Specificity: Recombinant and natural Mouse Platelet glycoprotein VI,GPVI
• Sequence Length: 313

• Samples: Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids
• Detection Range: 0.156-10 ng/mL
• Sensitivity: <0.093 ng/mL
• Intra-assay Precision: Intra-Assay CV: <=5.4%
• Inter-assay Precision: Inter-Assay CV: <=7.9%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for Gp6 elisa kit

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 244793038
• NCBI GeneID: 243816
• NCBI Accession #: NP_001156486.1
• NCBI GenBank Nucleotide #: NM_001163014.1
• UniProt Accession #: P0C191; E9QPN2
• Molecular Weight: 34,595 Da
• NCBI Official Full Name: platelet glycoprotein VI
• NCBI Official Synonym Full Names: glycoprotein 6 (platelet)
• NCBI Official Symbol: Gp6
• NCBI Official Synonym Symbols: Gpvi; Gm469; 9830166G18Rik
• NCBI Protein Information: platelet glycoprotein VI
• UniProt Protein Name: Platelet glycoprotein VI
• Protein Family: Platelet glycoprotein
• UniProt Gene Name: Gp6
• UniProt Synonym Gene Names: GPVI
• UniProt Entry Name: GPVI_MOUSE

Uniprot Description

GPVI: Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma- chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2. Defects in GP6 are the cause of bleeding disorder platelet-type 11 (BDPLT11). BDPLT11 is a mild to moderate bleeding disorder caused by defective platelet activation and aggregation in response to collagen. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: cell surface; integral to membrane; integral to plasma membrane; membrane

Molecular Function: collagen binding

Biological Process: blood coagulation; hemostasis