Goat Period Circadian Protein Homolog 1 (PER1) ELISA Kit | PER1 elisa kit

Goat Period Circadian Protein Homolog 1 (PER1) ELISA Kit

• Gene Names: PER1; PER; hPER; RIGUI
• Reactivity: Goat
• Synonyms: Period Circadian Protein Homolog 1 (PER1); Goat Period Circadian Protein Homolog 1 (PER1) ELISA Kit; PER1 elisa kit

• Reactivity: Goat
• Sequence Length: 1290

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 194097341
• NCBI GeneID: 5187
• NCBI Accession #: NP_002607.2
• NCBI GenBank Nucleotide #: NM_002616.2
• UniProt Accession #: O15534; B2RPA8; B4DI49; D3DTR3
• Molecular Weight: – Da
• NCBI Official Full Name: period circadian protein homolog 1
• NCBI Official Synonym Full Names: period circadian regulator 1
• NCBI Official Symbol: PER1
• NCBI Official Synonym Symbols: PER; hPER; RIGUI
• NCBI Protein Information: period circadian protein homolog 1
• UniProt Protein Name: Period circadian protein homolog 1
• Protein Family: Protein
• UniProt Gene Name: PER1
• UniProt Synonym Gene Names: KIAA0482; PER; RIGUI; hPER1

NCBI Description

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described. [provided by RefSeq, Jan 2014]

Uniprot Description

PER1: Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: chromatin DNA binding; kinase binding; protein binding; transcription factor binding; ubiquitin protein ligase binding

Biological Process: circadian regulation of gene expression; circadian rhythm; entrainment of circadian clock; entrainment of circadian clock by photoperiod; negative regulation of glucocorticoid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; posttranscriptional regulation of gene expression; regulation of circadian rhythm; regulation of cytokine production involved in inflammatory response; regulation of hair cycle; regulation of p38MAPK cascade; regulation of sodium ion transport; response to cAMP; transcription, DNA-dependent