GMPR2 recombinant protein

GMPR2, 1-348aa, Human, His tag, E Coli

Cat. Num. AAA203561

• Gene Names: GMPR2; GMPR 2
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: GMPR2; 1-348aa; Human; His tag; E Coli; Guanosine monophosphate reductase 2; GMP reductase 2; Guanosine 5'-monophosphate oxidoreductase 2; GMPR2 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 10% glycerol
• Concentration: 1mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFSFRN SKQTYSGVPI IAANMDTVGT FEMAKVLCKF SLFTAVHKHY SLVQWQEFAG QNPDCLEHLA ASSGTGSSDF EQLEQILEAI PQVKYICLDV ANGYSEHFVE FVKDVRKRFP QHTIMAGNVV TGEMVEELIL SGADIIKVGI GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM LGGMLAGHSE SGGELIERDG KKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD VEHTIRDILG GIRSTCTYVG AAKLKELSRR TTFIRVTQQV NPIFSEAC
• Sequence Length: 348

• Applicable Applications for GMPR2 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for GMPR2 recombinant protein

Guanosine monophosphate reductase 2, also known as GMPR2, is the only known metabolic step by which guanine nucleotides can be converted to the pivotal precursor of both adenine and guanine nucleotides. GMPR2 catalyzes the irreversible and NADPH-dependent reductive deamination of GMP to IMP, and plays a critical role in re-utilization of free intracellular bases and purine nucleosides. Recombinant human GMPR2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for GMPR2 recombinant protein

Enzymes & Proteases

References

Li J., et al. (2006) J Mol Biol. 355 (5):980-8.; Denq Y., et al. (2002) Int J Biochem Cell Biol. 34 (9):1035-50.;

NCBI and Uniprot Product Information

• NCBI GI #: 50541948
• NCBI GeneID: 51292
• NCBI Accession #: NP_001002002
• NCBI GenBank Nucleotide #: NM_001002002.2
• UniProt Accession #: Q9P2T1; Q567T0; Q6IAJ8; Q86T14; D3DS66
• Molecular Weight: 40 kDa (368aa), confirmed by MALDI-TOF
• NCBI Official Full Name: GMP reductase 2 isoform 2
• NCBI Official Synonym Full Names: guanosine monophosphate reductase 2
• NCBI Official Symbol: GMPR2
• NCBI Official Synonym Symbols: GMPR 2
• NCBI Protein Information: GMP reductase 2
• UniProt Protein Name: GMP reductase 2
• Protein Family: GMP reductase
• UniProt Gene Name: GMPR2
• UniProt Synonym Gene Names: GMPR 2; Guanosine monophosphate reductase 2

NCBI Description

This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Uniprot Description

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231).