Typical Testing Data/Standard Curve (for reference only)
Mouse Gamma-glutamyltranspeptidase 1 ELISA Kit | Ggt1 elisa kit
Mouse Gamma-glutamyltranspeptidase 1 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes gamma-glutamyl transpeptidase, a plasmamembrane-associated enzyme that cleaves the peptide bond between gamma-glutamyl and cysteinyl glycine moieties of glutathione. The encoded protein is autocatalytically processed to generate an enzymatically active heterodimer comprised of heavy and light chains. Mice lacking the encoded protein grow slowly, develop cataracts and have elevated levels of glutathione in plasma and urine. Transgenic overexpression of the encoded protein in mice enhances osteoclastic bone resorption. The mutant alleles termed 'Dwarf grey' and 'Dwarf grey Bayer' in mice are associated with deletions in this gene. A gamma-glutamyl transpeptidase paralog is located adjacent to this gene. Alternative splicing results in multiple transcript variants. Additional transcripts using alternate promoters and differing in 5' UTRs have been described. [provided by RefSeq, Apr 2015]
Uniprot Description
GGT1: Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive. Defects in GGT1 are a cause of glutathionuria (GLUTH); also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease. Belongs to the gamma-glutamyltransferase family. 3 isoforms of the human protein are produced by alternative promoter.
Protein type: Other Amino Acids Metabolism - cyanoamino acid; Other Amino Acids Metabolism - taurine and hypotaurine; Other Amino Acids Metabolism - glutathione; Membrane protein, integral; Transferase; EC 3.4.19.13; Other Amino Acids Metabolism - selenoamino acid; EC 3.4.19.14; Lipid Metabolism - arachidonic acid; EC 2.3.2.2
Cellular Component: extracellular space; integral to membrane; integral to plasma membrane; membrane; plasma membrane
Molecular Function: gamma-glutamyltransferase activity; hydrolase activity; peptidase activity; transferase activity; transferase activity, transferring acyl groups
Biological Process: cysteine biosynthetic process; glutamate metabolic process; glutathione biosynthetic process; glutathione catabolic process; glutathione metabolic process; leukotriene biosynthetic process; peptide modification; proteolysis; regulation of immune system process; regulation of inflammatory response; spermatogenesis; zymogen activation
Research Articles on Ggt1
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Product Notes
The Mouse Ggt1 ggt1 (Catalog #AAA288574) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA288574 ELISA Kit recognizes Mouse Ggt1. It is sometimes possible for the material contained within the vial of "Gamma-glutamyltranspeptidase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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