Growth and Differentiation factor 7 Active Protein | GDF7 active protein
Recombinant Human Growth and Differentiation factor 7
Gene Names
GDF7; BMP12
Purity
Greater than 95.0% as determined by SDS-PAGE.
Synonyms
Growth and Differentiation factor 7; Recombinant Human Growth and Differentiation factor 7; Growth Differentiation Factor 7; GDF-7; Growth/Differentiation Factor 7; BMP12; GDF7; GDF7 active protein
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
Lyophilized from a 0.2 um filtered solution in HCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sterile Filtered White lyophilized (freeze-dried) powder.
Sequence
TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR
Sequence Length
450
Source
Escherichia Coli.
Biological Activity
The ED50, as determined by inducing alkaline phosphatase production by mouse ATDC5 cells, is less than 1.25 ug/ml.
Solubility
It is recommended to reconstitute the lyophilized GDF-7 in sterile 18MOmega-cm H2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
Preparation and Storage
Lyophilized GDF7 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GDF-7 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Related Product Information for GDF7 active protein
Introduction: Growth Differentiation Factor-7 (GDF-7) belongs to the BMP family of TGF-b superfamily proteins. GDF7 elicits its bioactivity via a heterodimeric receptor complex comprised of a type 1 (BMPR-IB) and a type II (BMPR-II or Activin RII) serine/threonine kinase receptor. GDF7 signaling results in the phosphorylation and activation of Smad proteins. GDF-7 is also involved in tendon and ligament formation and repair. In addition, GDF7 regulates bone formation, mesenchymal stem cell differentiation, neuronal differentiation, and axon guidance.
Description: GDF7 Human Recombinant (322-450) produced in E Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 28kDa.The GDF-7 is purified by proprietary chromatographic techniques.
Description: GDF7 Human Recombinant (322-450) produced in E Coli is a disulfide-linked homodimeric, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 28kDa.The GDF-7 is purified by proprietary chromatographic techniques.
Product Categories/Family for GDF7 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
46,950 Da
NCBI Official Full Name
growth/differentiation factor 7 preproprotein
NCBI Official Synonym Full Names
growth differentiation factor 7
NCBI Official Symbol
GDF7
NCBI Official Synonym Symbols
BMP12
NCBI Protein Information
growth/differentiation factor 7
UniProt Protein Name
Growth/differentiation factor 7
Protein Family
UniProt Gene Name
GDF7
UniProt Synonym Gene Names
GDF-7
UniProt Entry Name
GDF7_HUMAN
Uniprot Description
GDF7: May play an active role in the motor area of the primate neocortex. Belongs to the TGF-beta family.
Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2p24.1
Cellular Component: extracellular space
Molecular Function: cytokine activity; protein binding; transforming growth factor beta receptor binding
Biological Process: activin receptor signaling pathway; BMP signaling pathway; cell development; positive regulation of transcription, DNA-dependent; regulation of apoptosis; regulation of MAPKKK cascade
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Product Notes
The GDF7 gdf7 (Catalog #AAA140620) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: TALAGTRTAQ GSGGGAGRGH GRRGRSRCSR KPLHVDFKEL GWDDWIIAPL DYEAYHCEGL CDFPLRSHLE PTNHAIIQTL LNSMAPDAAP ASCCVPARLS PISILYIDAA NNVVYKQYED MVVEACGCR. It is sometimes possible for the material contained within the vial of "Growth and Differentiation factor 7, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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