Rabbit anti-Human GPR141 Polyclonal Antibody | anti-GPR141 antibody

GPR141 polyclonal antibody

Cat. Num. AAA3014831

• Gene Names: GDF7; BMP12
• Reactivity: Human
• Applications: Western Blot
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR141; Polyclonal Antibody; GPR141 polyclonal antibody; Growth/differentiation factor 7; GDF-7; GDF7; anti-GPR141 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: GDF7 polyclonal antibody detects endogenous levels of GDF7 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR141 antibody: Western Blot (WB)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human GDF7
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of GDF7 polyclonal antibody at 1:500 dilutionLaneA: HCT116 whole cell lysateLaneB: HepG2 whole cell lysate)

Related Product Information for anti-GPR141 antibody

Growth/differentiation factors (GDFs) are members of the TGF superfamily. Members of the TGF superfamily are involved in embryonic development and adult tissue homeostasis. GDF-1 expression is almost exclusively restricted to the central nervous system and mediates cell differentiation events during embryonic development. Neither GDF-3 (Vgr-2) nor GDF-9 contains the conserved cysteine residue which is found in most other TGF superfamily members. GDF-3 is detectable in bone marrow, spleen, thymus and adipose tissue, whereas GDF-9 has only been detected in ovary. GDF-5 (also designated CDMP-1) has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. GDF-5 mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs. GDF-6 and GDF-7 are closely related to GDF-5. GDF-8 has been shown to be a negative regulator of skeletal muscle mass.

NCBI and Uniprot Product Information

• NCBI GI #: 61835232
• NCBI GeneID: 151449
• NCBI Accession #: NP_878248.2
• NCBI GenBank Nucleotide #: NM_182828.2
• UniProt Accession #: Q7Z4P5
• Molecular Weight: 46,950 Da
• NCBI Official Full Name: growth/differentiation factor 7 preproprotein
• NCBI Official Synonym Full Names: growth differentiation factor 7
• NCBI Official Symbol: GDF7
• NCBI Official Synonym Symbols: BMP12
• NCBI Protein Information: growth/differentiation factor 7; GDF-7
• UniProt Protein Name: Growth/differentiation factor 7
• Protein Family: Probable G-protein coupled receptor
• UniProt Gene Name: GDF7
• UniProt Synonym Gene Names: GDF-7
• UniProt Entry Name: GDF7_HUMAN

NCBI Description

This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]

Uniprot Description

GDF7: May play an active role in the motor area of the primate neocortex. Belongs to the TGF-beta family.

Protein type: Cytokine; Secreted, signal peptide; Cell development/differentiation; Secreted

Chromosomal Location of Human Ortholog: 2p24.1

Cellular Component: extracellular space

Molecular Function: protein binding; protein homodimerization activity; growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: axon guidance; cell fate commitment; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; roof plate formation; forebrain morphogenesis; BMP signaling pathway; regulation of apoptosis; epithelial cell differentiation; branching morphogenesis of a tube; regulation of MAPKKK cascade; midbrain development; spinal cord association neuron differentiation; gland morphogenesis; positive regulation of neuron differentiation; cell development; reproductive structure development; growth