GAGA-POZ Domain, aa1-130aa, Drosophila melanogaster Recombinant Protein

GAGA-POZ Domain, aa1-130aa, Recombinant, Drosophila melanogaster

Cat. Num. AAA636658

• Purity: Highly Purified; 95% by SDS PAGE; Purified by conventional column chromatography techniques.
• Synonyms: GAGA-POZ Domain; aa1-130aa; Drosophila melanogaster; Recombinant; Drosophila melanogaster recombinant protein

• Host: E Coli
• Purity/Purification: Highly Purified; 95% by SDS PAGE; Purified by conventional column chromatography techniques.
• Form/Format: Supplied as a liquid in 10mM HEPES, pH 7.4 and 25mM sodium chloride.
• Sequence: MSLPMNSLYS/ LTWGDYGTSL/ VSAIQLLRCH/ GDLVDCTLAA/ GGRSFPAHKI/ VLCAASPFLL/; DLLKNTPCKH/ PVVMLAGVNA/ NDLEALLEFV/ YRGEVSVDHA/ QLPSLLQAAQ/ CLNIQGLAPQ/; TVTKDDYTTH

• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for GAGA-POZ Domain, aa1-130aa, Drosophila melanogaster recombinant protein

The GAGA factor is a sequence-specific DNA-binding protein, which participates in the regulation of the expression of a variety of different classes of genes in Drosophila such as many developmentally regulated genes, stress induced genes, and cell cycle regulated genes, as well as housekeeping genes. GAGA contains a C-terminal glutamine-rich domain and a highly conserved N-terminal POZ domain which reported to be involved in self-oligomerization in a number of other POZ domain containing proteins. In case of GAGA protein, the N-terminal POZ

Product Categories/Family for GAGA-POZ Domain, aa1-130aa, Drosophila melanogaster recombinant protein

Molecular Biology; MB-Binding Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 347513
• Molecular Weight: 14kD
• NCBI Official Full Name: GAGA transcription factor

Uniprot Description

Transcriptional activator that functions by regulating chromatin structure. Overcomes the repressive effects of chromatin by promoting the open chromatin conformation in promoter gene regions, thereby allowing access to other transcription factors. Binds to DNA Polycomb response elements (PREs) at the bithorax complex and to the proximal region of the engrailed promoter, and positively regulates transcription of many genes including homeotic ones. Binds to the DNA sequence (GA)n, with optimal binding to the pentamer 5'-GAGAG-3'. Binds DNA as an oligomer. May also act as a transcriptional repressor, maintaining the repressed state of genes including lolal, and down-regulating its own transcription. Required for dosage compensation in males and may be involved in oogenesis. Also has a role in nuclear division.