Gamma-Aminobutyric Acid A Receptor Alpha 2 Recombinant Protein | gABRa2 recombinant protein

Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 2 (gABRa2)

Cat. Num. AAA2034405

• Reactivity: Human
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >90%
• Synonyms: Gamma-Aminobutyric Acid A Receptor Alpha 2; Recombinant Gamma-Aminobutyric Acid A Receptor Alpha 2 (gABRa2); GABA(A) receptor subunit alpha-2; gABRa2 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: >90%
• Sequence Length: 451

• Applicable Applications for gABRa2 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Phe42~Ile250
• Tag: Two N-terminal Tags, His-tag and GST-tag
• Expression System: Prokaryotic Expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 167000751
• NCBI GeneID: 2555
• NCBI Accession #: NP_000798.2
• NCBI GenBank Nucleotide #: NM_000807.2
• Molecular Weight: 54.1kDa
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit alpha-2 isoform a
• NCBI Official Synonym Full Names: gamma-aminobutyric acid type A receptor alpha2 subunit
• NCBI Official Symbol: GABRA2
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit alpha-2
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit alpha-2
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: GABRA2
• UniProt Entry Name: GBRA2_HUMAN

NCBI Description

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Uniprot Description

GABRA2: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 4p12

Cellular Component: axon; cell junction; integral to synaptic vesicle membrane; plasma membrane; postsynaptic membrane

Molecular Function: benzodiazepine receptor activity; chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity

Biological Process: gamma-aminobutyric acid signaling pathway; neurotransmitter transport; regulation of neurotransmitter levels; synaptic transmission; transmembrane transport

Disease: Alcohol Dependence