GTPase Activating Protein Recombinant Protein | G3BP2 recombinant protein

Recombinant Human GTPase Activating Protein (SH3 domain) Binding Protein 2

Cat. Num. AAA144418

• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: GTPase Activating Protein; Recombinant Human GTPase Activating Protein (SH3 domain) Binding Protein 2; G3BP2 Human; GTPase Activating Protein (SH3 domain) Binding Protein 2 Human Recombinant; Ras GTPase-activating protein-binding protein 2; G3BP-2; GAP SH3 domain-binding protein 2; G3BP2; KIAA0660; G3BP2 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The G3BP2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 30% glycerol, 0.2M NaCl, 2mM DTT and 0.1mM PMSF.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMVMEKP SPLLVGREFV RQYYTLLNKA PEYLHRFYGR NSSYVHGGVD ASGKPQEAVY GQNDIHHKVL SLNFSECHTK IRHVDAHATL SDGVVVQVMG LLSNSGQPER KFMQTFVLAP EGSVPNKFYV HNDMFRYEDE VFGDSEPELD EESEDEVEEE QEERQPSPEP VQENANSGYY EAHPVTNGIE EPLEESSHEP EPEPESETKT EELKPQVEEK NLEELEEKST TPPPAEPVSL PQEPPKPRVE AKPEVQSQPP RVREQRPRER PGFPPRGPRP GRGDMEQNDS DNRRIIRYPD SHQLFVGNLP HDIDENELKE FFMSFGNVVE LRINTKGVGG KLPNFGFVVF DDSEPVQRIL IAKPIMFRGE VRLNVEEKKT RAARERETRG GGDDRRDIRR NDRGPGGPRG IVGGGMMRDR DGRGPPPRGG MAQKLGSGRG TGQMEGRFTG QRR
• Sequence Length: 482

• Preparation and Storage: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Related Product Information for G3BP2 recombinant protein

Description: G3BP2 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 473 amino acids (1-449) and having a molecular mass of 53.3kDa.G3BP2 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Ras GTPase-activating protein-binding protein 2 (G3BP2) is restricted to the plasma membrane and endocytic compartments and controls a fast endocytic recycling pathway. G3BP2 may be a scaffold protein which might be involved in mRNA transport.

Product Categories/Family for G3BP2 recombinant protein

Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 19923399
• NCBI GeneID: 9908
• NCBI Accession #: NP_036429.2
• NCBI GenBank Nucleotide #: NM_012297.4
• UniProt Accession #: Q9UN86; O60606; O75149; Q9UPA1; A8K6X1
• Molecular Weight: 50,817 Da
• NCBI Official Full Name: ras GTPase-activating protein-binding protein 2 isoform a
• NCBI Official Synonym Full Names: GTPase activating protein (SH3 domain) binding protein 2
• NCBI Official Symbol: G3BP2
• NCBI Protein Information: ras GTPase-activating protein-binding protein 2; G3BP-2; GAP SH3 domain-binding protein 2; Ras-GTPase activating protein SH3 domain-binding protein 2
• UniProt Protein Name: Ras GTPase-activating protein-binding protein 2
• Protein Family: GTPase activating protein
• UniProt Gene Name: G3BP2
• UniProt Synonym Gene Names: KIAA0660; G3BP-2
• UniProt Entry Name: G3BP2_HUMAN

Uniprot Description

G3BP-2: an hnRNA-binding protein and an element of the Ras signal transduction pathway. A DNA-unwinding enzyme which can unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. Binds specifically to the Ras-GTPase-activating protein (GAP120) by associating with its SH3 domain. Interacts with USP10, and may regulate it. Several alternatively spliced transcript variants have been described.

Protein type: Adaptor/scaffold; RNA-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21.1

Cellular Component: cytoplasm

Molecular Function: receptor signaling complex scaffold activity; nucleotide binding

Biological Process: cytoplasmic sequestering of NF-kappaB; mRNA transport; Ras protein signal transduction