Fibrinogen Silencer Binding Protein Recombinant Protein | FSBP recombinant protein

Recombinant Human Fibrinogen Silencer Binding Protein

Cat. Num. AAA145615

• Gene Names: RAD54B; RDH54
• Purity: Greater than 85.0% as determined by SDS-PAGE.
• Synonyms: Fibrinogen Silencer Binding Protein; Recombinant Human Fibrinogen Silencer Binding Protein; FSBP Human; Fibrinogen Silencer Binding Protein Human Recombinant; Fibrinogen silencer-binding protein; FSBP; FSBP recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 85.0% as determined by SDS-PAGE.
• Form/Format: FSBP protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 1M Urea and 10% glycerol.; Sterile Filtered clear solution.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMVGKARS SNFTLSEKLD LLKLVKPYVK ILEEHTNKHS VIVEKNRCWD IIAVNYNAIG VDRPPRTAQG LRTLYKRLKE YAKQELLQQK ETQSDFKSNI SEPTKKVMEM IPQISSFCLV RDRNHIQSAN LDEEAQAGTS SLQVMLDHHP VAITVEVKQE EDIKPPPPLV LNSQQSDTLE QREEHELVHV MERSLSPSLS SVDMRMTSSP SSIPRRDDFF RHESGEHFRS LLGYDPQILQ MLKEEHQIIL ENQKNFGLYV QEKRDGLKRR QQLEEELLRA KIEVEKLKAI RLRHDLPEYN SL
• Sequence Length: 117

Related Product Information for FSBP recombinant protein

Description: FSBP Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 322 amino acids (1-299 a.a.) and having a molecular mass of 37.2kDa.FSBP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Fibrinogen silencer-binding protein (FSBP), interacts with X11alpha. The X11alpha/FSBP complex send signals to the nucleus in order to repress glycogen synthase kinase-3beta promoter activity. X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) via a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's diseased brains.

Product Categories/Family for FSBP recombinant protein

Recombinant & Natural Proteins; Recombinant Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 327532738
• NCBI GeneID: 25788
• NCBI Accession #: NP_001192191.1
• NCBI GenBank Nucleotide #: NM_001205262.2
• UniProt Accession #: O95073; Q8N4S5; Q9Y620
• Molecular Weight: 18,626 Da
• NCBI Official Full Name: DNA repair and recombination protein RAD54B isoform 2
• NCBI Official Synonym Full Names: RAD54 homolog B (S. cerevisiae)
• NCBI Official Symbol: RAD54B
• NCBI Official Synonym Symbols: RDH54
• NCBI Protein Information: DNA repair and recombination protein RAD54B
• UniProt Protein Name: Fibrinogen silencer-binding protein
• Protein Family: Fibrinogen silencer-binding protein
• UniProt Gene Name: FSBP
• UniProt Entry Name: FSBP_HUMAN

NCBI Description

The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer. [provided by RefSeq, Jul 2008]

Uniprot Description

FSBP: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1. Interacts with APBA1 (via PDZ 1 and 2 domains). 2 isoforms of the human protein are produced by alternative splicing

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nucleus

Molecular Function: DNA helicase activity; DNA binding; DNA translocase activity; RNA helicase activity; ATP binding

Biological Process: mitotic recombination; meiotic recombination; DNA duplex unwinding; double-strand break repair via homologous recombination