FGF21 recombinant protein

Mouse FGF21 Protein, His Tag

Cat. Num. AAA9718724

• Purity: >85% as determined by SDS-PAGE
• Synonyms: FGF21; Mouse FGF21 Protein; His Tag; Recombinant Mouse FGF21 Protein; His Tag (Fibroblast growth factor 21) expressed in Human Cells; FGF-21; Fibroblast growth factor 21; FGF21 recombinant protein

• Host: Human Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence: Amino acid sequence derived from mouse FGF21 (Q9JJN1) (Met 1-Ser 210) was expressed, with a polyhistidine tag at the C-terminus.
• Sequence Length: 210

• Species: Mouse
• Endotoxin: The Endotoxin level is less than 1.0 EU per mug of the protein as determined by the LAL method; Protein Length
• Usage Notes: Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse FGF21 protein, His Tag in sterile ddH2O not less than 100ug/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Item should be stored desiccated below -20 degree C. Upon reconstitution, the protein should be stored at 4 degree C between 2-7 days and for future use below -20 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

SDS-Page

(Fig.SDS-PAGE analysis of Mouse FGF21 protein, His Tag.)

Related Product Information for FGF21 recombinant protein

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-21 has a hydrophobic amino terminus, which is a typical signal sequence, and appears to be a secreted protein. The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic properties in animal models of diabetes and obesity. FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans. The paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF21, warrants further investigation. FGF-21, which we have identified as a novel metabolic factor, exhibits the therapeutic characteristics necessary for an effective treatment of diabetes.

NCBI and Uniprot Product Information

• NCBI GI #: 9910218
• NCBI GeneID: 56636
• NCBI Accession #: NP_064397.1
• NCBI GenBank Nucleotide #: NP_064397.1
• UniProt Accession #: Q9JJN1
• Molecular Weight: 21.3 kDa
• NCBI Official Full Name: fibroblast growth factor 21
• NCBI Official Synonym Full Names: fibroblast growth factor 21
• NCBI Official Symbol: Fgf21
• NCBI Protein Information: fibroblast growth factor 21
• UniProt Protein Name: Fibroblast growth factor 21
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: Fgf21
• UniProt Synonym Gene Names: FGF-21
• UniProt Entry Name: FGF21_MOUSE

Uniprot Description

FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Biological Process: positive regulation of cell proliferation; positive regulation of glucose import