FcRn & B2M Heterodimer Recombinant Protein | FCGRT recombinant protein

Recombinant Human FcRn & B2M Heterodimer Protein (C-6His)

Cat. Num. AAA2552658

• Gene Names: FCGRT; FCRN; alpha-chain
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: FcRn & B2M Heterodimer; Recombinant Human FcRn & B2M Heterodimer Protein (C-6His); IgG receptor FcRn; Neonatal Fc receptor; FCRN; FCGRT recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 50mM HEPES, 150mM NaCl, pH 7.4.
• Sequence Positions: Ala24-Leu290 & Ile21-Met119
• Sequence Length: 365

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for FCGRT recombinant protein

FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51(alpha chain) and Beta-2-microglobulin(Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk, Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog (FcRn) and beta-2-microglobulin (B2M).

NCBI and Uniprot Product Information

• NCBI GI #: 209862839
• NCBI GeneID: 2217
• NCBI Accession #: NP_001129491.1
• NCBI GenBank Nucleotide #: NM_001136019.2
• UniProt Accession #: P55899; Q5HYM5; Q9HBV7; Q9NZ19
• Molecular Weight: Molecular Mass: 41.4 kDa; Actual Protein Molecular Mass: 13; 37 kDa
• NCBI Official Full Name: IgG receptor FcRn large subunit p51
• NCBI Official Synonym Full Names: Fc fragment of IgG receptor and transporter
• NCBI Official Symbol: FCGRT
• NCBI Official Synonym Symbols: FCRN; alpha-chain
• NCBI Protein Information: IgG receptor FcRn large subunit p51
• UniProt Protein Name: IgG receptor FcRn large subunit p51
• Protein Family: IgG receptor
• UniProt Gene Name: FCGRT
• UniProt Synonym Gene Names: FCRN; FcRn

NCBI Description

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Uniprot Description

Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7964511, PubMed:10933786). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (). Possible role in transfer of immunoglobulin G from mother to fetus (PubMed:7964511).