Fcgrt recombinant protein

Fcgrt, 22-297aa, Mouse, His-tag, Baculovirus

Cat. Num. AAA206492

• Gene Names: Fcgrt; FcRn
• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: Fcgrt; 22-297aa; Mouse; His-tag; Baculovirus; IgG receptor FcRn large subunit p51; FcRn; Fcgrt recombinant protein

• Host: Baculovirus
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ADPSETRPPL MYHLTAVSNP STGLPSFWAT GWLGPQQYLT YNSLRQEADP CGAWMWENQV SWYWEKETTD LKSKEQLFLE ALKTLEKILN GTYTLQGLLG CELASDNSSV PTAVFALNGE EFMKFNPRIG NWTGEWPETE IVANLWMKQP DAARKESEFL LNSCPERLLG HLERGRRNLE WKEPPSMRLK ARPGNSGSSV LTCAAFSFYP PELKFRFLRN GLASGSGNCS TGPNGDGSFH AWSLLEVKRG DEHHYQCQVE HEGLAQPLTV DLDSSARSSH HHHHH
• Sequence Length: 365

• Applicable Applications for Fcgrt recombinant protein: SDS-PAGE
• Antigen Species: Mouse
• Tag Information: His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for Fcgrt recombinant protein

Fcgrt, as known as IgG receptor FcRn large subunit p51, is a transmembrane glycoprotein with structural homology to MHC class 1 proteins. This protein is widely expressed in endothelial and epithelial cells and plays an important rloe in IgG homeostasis. Also, it is expessed in neutrophils and myeloid antigen presenting cells. It can enhance IgG-meditated phagocytosis and antigen presentation by heses cells, but it promotes the degradation of opsonizing IgG rather than returning it to the circulation. Recombinant mouse Fcgrt, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for Fcgrt recombinant protein

Immunology

References

Baker K., et al, (2013) Immunity 39:1095-1107.; Paveglio S., et al, (2012) Clin. Exp. Allergy 42:1791-1800.

NCBI and Uniprot Product Information

• NCBI GI #: 170172528
• NCBI GeneID: 14132
• NCBI Accession #: NP_034319
• NCBI GenBank Nucleotide #: NM_010189.3
• UniProt Accession #: Q61559; Q9QUR0; Q9R2A5
• Molecular Weight: 32.1kDa (285aa) 40-57kDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: IgG receptor FcRn large subunit p51 isoform 1
• NCBI Official Synonym Full Names: Fc receptor, IgG, alpha chain transporter
• NCBI Official Symbol: Fcgrt
• NCBI Official Synonym Symbols: FcRn
• NCBI Protein Information: IgG receptor FcRn large subunit p51
• UniProt Protein Name: IgG receptor FcRn large subunit p51
• Protein Family: IgG receptor
• UniProt Gene Name: Fcgrt
• UniProt Synonym Gene Names: Fcrn; FcRn

Uniprot Description

Binds to the Fc region of monomeric immunoglobulins gamma (PubMed:7504013). Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids (). Possible role in transfer of immunoglobulin G from mother to fetus ().