Fas Ligand Recombinant Protein | FASLG recombinant protein

Fas Ligand Protein, Rat, Recombinant (His Tag)

Cat. Num. AAA8123334

• Gene Names: Faslg; Fasl; CD95-L; Tnfsf6; Tnlg1a; Apt1Lg1
• Purity: >95% as determined by SDS-PAGE
• Synonyms: Fas Ligand; Fas Ligand Protein; Rat; Recombinant (His Tag); Rat Fas Ligand/FASLG/CD95L Protein (His Tag); Fas ligand; FASLG recombinant protein

• Host: Yeast
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Leu104-Leu278

• Species: Rat
• Predicted N Terminal: His
• Tag: N-His
• Protein Construction: A DNA sequence encoding the rat Faslg (NP_037040.1)(Leu104-Leu278) was expressed with a polyhistidine tag at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FASLG recombinant protein

Background: Fas Ligand, also known as FASLG and CD95L, is the ligand for FAS. It is a transmembrane protein which binds to TNFRSF6/FAS. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Product Categories/Family for FASLG recombinant protein

Death Receptor Signaling

References

Pitti R M. et al., 1998, Nature. 396 (6712): 699-703. Hane M. et al., 1995, FEBS Lett. 373 (3): 265-8. Schneider P. et al., 1997, J Biol Chem. 272 (30): 18827-33.

NCBI and Uniprot Product Information

• NCBI GI #: 6978525
• NCBI GeneID: 25385
• NCBI Accession #: NP_037040.1
• NCBI GenBank Nucleotide #: NM_012908.1
• UniProt Accession #: P36940
• Molecular Weight: 31,140 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 6
• NCBI Official Synonym Full Names: Fas ligand
• NCBI Official Symbol: Faslg
• NCBI Official Synonym Symbols: Fasl; CD95-L; Tnfsf6; Tnlg1a; Apt1Lg1
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 6
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 6
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: Faslg
• UniProt Synonym Gene Names: Apt1Lg1; Cd95l; Fasl; Tnfsf6; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA

NCBI Description

ligand that binds the Fas receptor; plays a role in induction of apoptosis [RGD, Feb 2006]

Uniprot Description

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects ().