TAFA2/FAM19A2 Recombinant Protein | FAM19A2 recombinant protein

TAFA2/FAM19A2 Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8120714

• Gene Names: FAM19A2; TAFA2; TAFA-2
• Purity: >79% as determined by SDS-PAGE
• Synonyms: TAFA2/FAM19A2; TAFA2/FAM19A2 Protein; Human; Recombinant (hFc Tag); Human FAM19A2 Protein (Fc Tag); TAFA-2 Protein; TAFA2 Protein; family with sequence similarity 19 (chemokine (C-C motif)-like); member A2; FAM19A2 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >79% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ala31-His131

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Glu
• Tag: N-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human FAM19A2 (Q8N3H0-1)(Ala31-His131) was expressed, fused with the Fc region of human IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for FAM19A2 recombinant protein

Background: FAM19A2 belongs to the FAM19/TAFA family. FAM19/TAFA family members are chemokine-like proteins. The biological functions of TAFA family members remain to be determined, but there are a few tentative hypotheses. First, TAFAs may modulate immune responses in the CNS by functioning as brain specific chemokines, and may act with other chemokines to optimize the recruitment and activity of immune cells in the CNS. Second, TAFAs may represent a novel class of neurokines that act as regulators of immune nervous cells. And third, TAFAs may control axonal sprouting following brain injury. Human FAM19A2 is 97% aa identical to mouse FAM19A2 and is expressed in the central nervous system (CNS), colon, heart, lung, spleen, kidney, and thymus, however its expression in the CNS is 50 to 1000 fold higher than in other tissues. FAM19A2 gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins.

References

Parsa A, et al. (2011) Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. Clin Transl Sci. 4(1):17-23.Rose JE, et al. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med. 16(7-8):247-53.Trynka G, et al. (2009) Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Gut. 58(8):1078-83.

NCBI and Uniprot Product Information

• NCBI GI #: 30425496
• NCBI GeneID: 338811
• NCBI Accession #: NP_848634.1
• NCBI GenBank Nucleotide #: NM_178539.4
• UniProt Accession #: Q8N3H0; Q4G0R9; Q68DK0; Q6GTX6; B3KVV4
• Molecular Weight: 3,805 Da
• NCBI Official Full Name: protein FAM19A2
• NCBI Official Synonym Full Names: family with sequence similarity 19 member A2, C-C motif chemokine like
• NCBI Official Symbol: FAM19A2
• NCBI Official Synonym Symbols: TAFA2; TAFA-2
• NCBI Protein Information: protein FAM19A2
• UniProt Protein Name: Protein FAM19A2
• Protein Family: Protein
• UniProt Gene Name: FAM19A2
• UniProt Synonym Gene Names: TAFA2

NCBI Description

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]