Fatty Acid-Binding Protein 5 Recombinant Protein | FABP5 recombinant protein

Recombinant Human Fatty Acid-Binding Protein 5

Cat. Num. AAA2556629

• Gene Names: FABP5; EFABP; KFABP; E-FABP; PAFABP; PA-FABP
• Purity: >90% as determined by reducing SDS-PAGE.
• Synonyms: Fatty Acid-Binding Protein 5; Recombinant Human Fatty Acid-Binding Protein 5; Fatty Acid-Binding Protein Epidermal; Epidermal-Type Fatty Acid-Binding Protein; E-FABP; Psoriasis-Associated Fatty Acid-Binding Protein Homolog; PA-FABP; FABP5; FABP5 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Length: 135

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Fragment: Ala2-Glu135
• Fusion Tag: N-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for FABP5 recombinant protein

Protein Construction: Recombinant Human Fatty Acid-Binding Protein 5 is produced by our E Coli expression system and the target gene encoding Ala2-Glu135 is expressed with a 6His tag at the N-terminus.

Background: Fatty acid-binding protein 5 (FABP5) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP5 can be expressed in keratinocytes, and is highly expressed in psoriatic skin. FABP5 has been shown to be involved in keratinocyte differentiation. FABP5 has high specificity for fatty acids, the highest affinity for C18 chain length. FABP5 can decrease the chain length or introduce double bonds to reduce the affinity.

NCBI and Uniprot Product Information

• NCBI GI #: 4557581
• NCBI GeneID: 2171
• NCBI Accession #: NP_001435.1
• NCBI GenBank Nucleotide #: NM_001444.3
• UniProt Accession #: Q01469; B2R4K0
• Molecular Weight: Molecular Mass: 17.3kDa; Actual Protein Molecular Mass: 16kDa
• NCBI Official Full Name: fatty acid-binding protein 5
• NCBI Official Synonym Full Names: fatty acid binding protein 5
• NCBI Official Symbol: FABP5
• NCBI Official Synonym Symbols: EFABP; KFABP; E-FABP; PAFABP; PA-FABP
• NCBI Protein Information: fatty acid-binding protein 5
• UniProt Protein Name: Fatty acid-binding protein 5
• Protein Family: Fatty acid-binding protein
• UniProt Gene Name: FABP5
• UniProt Synonym Gene Names: E-FABP1 PublicationManual assertion based on opinion iniRef.9; PA-FABP

NCBI Description

This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]

Uniprot Description

Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (). May be involved in keratinocyte differentiation (PubMed:8092987).