CD321 recombinant protein

Recombinant Human CD321 protein, C-His Tag

Cat. Num. AAA1560642

• Gene Names: F11R; JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD321; Recombinant Human CD321 protein; C-His Tag; F11R JAM1; JCAM; UNQ264/PRO301; CD321 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Tag: C-His Tag
• Species: Homo sapiens (Human)
• Endotoxin Level: <1.0EU per ug of the protein as determined by the LAL method.
• Protein Construction: A DNA sequence encoding the human F11R (Met1-Val238) was fused with the C-terminal His Tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

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Product Categories/Family for CD321 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 8393638
• NCBI GeneID: 50848
• NCBI Accession #: NP_058642.1
• NCBI GenBank Nucleotide #: NM_016946.4
• UniProt Accession #: Q9Y624
• Molecular Weight: 32,583 Da
• NCBI Official Full Name: junctional adhesion molecule A
• NCBI Official Synonym Full Names: F11 receptor
• NCBI Official Symbol: F11R
• NCBI Official Synonym Symbols: JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
• NCBI Protein Information: junctional adhesion molecule A; platelet F11 receptor; platelet adhesion molecule 1; junctional adhesion molecule 1
• UniProt Protein Name: Junctional adhesion molecule A
• UniProt Gene Name: F11R
• UniProt Synonym Gene Names: JAM1; JCAM; JAM-A; JAM-1; PAM-1
• UniProt Entry Name: JAM1_HUMAN

NCBI Description

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]

Uniprot Description

JAM-A: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 1q21.2-q21.3

Cellular Component: microtubule cytoskeleton; tight junction; integral to membrane; plasma membrane; intercellular junction; cytoplasmic vesicle; cell junction

Molecular Function: protein binding; PDZ domain binding

Biological Process: intercellular junction assembly and maintenance; response to radiation; extracellular matrix organization and biogenesis; viral reproduction; transforming growth factor beta receptor signaling pathway; actomyosin structure organization and biogenesis; inflammatory response; cell adhesion; blood coagulation; leukocyte migration; positive regulation of blood pressure; intestinal absorption