ESRP1 recombinant protein

Recombinant Human ESRP1

Gene Names

ESRP1; RBM35A; RMB35A

Applications

Western Blot, ELISA

Purity

Greater than 85% by SDS-PAGE gel analyses

Synonyms

ESRP1; Recombinant Human ESRP1; RBM35A; RNA binding motif protein 35A; RNA binding protein 35A; ESRP1 recombinant protein

Ordering
Cat. Num. AAA7614753 For Research Use Only!

Host

E Coli

Purity/Purification

Greater than 85% by SDS-PAGE gel analyses

Form/Format

Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose and 0.06% proclin, pH7.4

Sequence Positions

23-228

Applicable Applications for ESRP1 recombinant protein

Western Blot (WB), ELISA (EIA)

Species

Human

Tag

N-terminal His-IF2DI Tag

Reconstitution

Centrifuge the vial at 10,000rpm for 1 minute, reconstitute at 200ug/ml in sterile distilled water

Preparation and Storage

Store at -20 degree C for 12 months as lyophilized; 2-8 degree C for 1 month under sterile conditions after reconstitution

NCBI and Uniprot Product Information

NCBI GI #

56790297

NCBI GeneID

54845

NCBI Accession #

NP_001030087

NCBI GenBank Nucleotide #

NM_017697.3

UniProt Accession #

Q6NXG1; Q2M2B0; Q499G3; Q6PJ86; Q9NXL8; A6NHA8; A8MPX1; E9PB47

Molecular Weight

73,133 Da

NCBI Official Full Name

epithelial splicing regulatory protein 1 isoform 1

NCBI Official Synonym Full Names

epithelial splicing regulatory protein 1

NCBI Official Symbol

ESRP1

NCBI Official Synonym Symbols

RBM35A; RMB35A

NCBI Protein Information

epithelial splicing regulatory protein 1; RNA-binding protein 35A; RNA binding motif protein 35A; RNA-binding motif protein 35A

UniProt Protein Name

Epithelial splicing regulatory protein 1

Protein Family

Epithelial splicing regulatory protein

UniProt Gene Name

ESRP1

UniProt Synonym Gene Names

RBM35A

UniProt Entry Name

ESRP1_HUMAN

NCBI Description

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]

Uniprot Description

RBM35A: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Belongs to the ESRP family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA processing

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nucleus

Molecular Function: mRNA binding; nucleotide binding

Biological Process: regulation of RNA splicing; RNA splicing; mRNA processing

Research Articles on ESRP1

1. ESRP1 and ESRP2 suppress cancer cell motility via different mechanisms.

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Product Notes

The ESRP1 esrp1 (Catalog #AAA7614753) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-228. AAA Biotech's ESRP1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). Researchers should empirically determine the suitability of the ESRP1 esrp1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ESRP1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.