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ERN2 Blocking Peptide | ERN2 (HGNC:16942) blocking peptide

ERN2 Antibody (C-term) Blocking Peptide

Gene Names
ERN2; IRE1b; IRE2p; hIRE2p; IRE1-BETA
Synonyms
ERN2; ERN2 Antibody (C-term) Blocking Peptide; Serine/threonine-protein kinase/endoribonuclease IRE2; Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; hIRE2p; Ire1-beta; IRE1b; Serine/threonine-protein kinase; Endoribonuclease; 3126-; ERN2 (HGNC:16942) blocking peptide
Ordering
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human ERN2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Sequence Length
926
Cellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for ERN2 (HGNC:16942) blocking peptide
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
102,480 Da
NCBI Official Full Name
Serine/threonine-protein kinase/endoribonuclease IRE2
NCBI Official Synonym Full Names
endoplasmic reticulum to nucleus signaling 2
NCBI Official Symbol
ERN2
NCBI Official Synonym Symbols
IRE1b; IRE2p; hIRE2p; IRE1-BETA
NCBI Protein Information
serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Protein Name
Serine/threonine-protein kinase/endoribonuclease IRE2
UniProt Gene Name
ERN2
UniProt Synonym Gene Names
hIRE2p; IRE1b
UniProt Entry Name
ERN2_HUMAN

Uniprot Description

IRE2: Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Protein type: Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Apoptosis; Protein kinase, Other; Kinase, protein; Ribonuclease; Other group; IRE family

Chromosomal Location of Human Ortholog: 16p12.2

Molecular Function: ATP binding; endonuclease activity; magnesium ion binding; protein serine/threonine kinase activity

Biological Process: apoptotic chromosome condensation; negative regulation of transcription, DNA-dependent; protein amino acid phosphorylation; rRNA catabolic process

Research Articles on ERN2 (HGNC:16942)

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Product Notes

The ERN2 (HGNC:16942) ern2 (Catalog #AAA9226608) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ERN2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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