VE-Statin/EGFL-7 recombinant protein

Human VE-Statin/EGFL7

Cat. Num. AAA692160

• Gene Names: EGFL7; NEU1; ZNEU1; VE-STATIN; RP11-251M1.2
• Reactivity: Human
• Purity: > 95% by SDS-PAGE & silver stain
• Synonyms: VE-Statin/EGFL-7; Human VE-Statin/EGFL7; Recombinant Human VE-Statin/EGFL7; EGF-like protein 7; Vascular endothelial statin; Multiple EGF-like domains protein 7; VE-Statin/EGFL-7 recombinant protein

• Host: Insect Cells
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE & silver stain
• Form/Format: Lyophilized
• Sequence Length: 211

• Buffer: Water
• Preparation and Storage: Lyophilized samples are stable for greater than six months at -20 degree C to -70 degree C. Reconstituted EGFL7 should be stored in working aliquots at -20 degree C. Avoid repeated freeze-thaw cycles!

Testing Data

Related Product Information for VE-Statin/EGFL-7 recombinant protein

EGFL7 (VE-Statin) is an ~ 30 kDa secreted protein that contains an Emilin-like (EMI) domain (a multimerization motif), and two epidermal growth factor (EGF) domains, one of which binds calcium. Based on these domains, it has been hypothesized that EGFL7 may self-assemble like extracellular matrix (ECM) proteins and, thus, could incorporate into ECM. EGFL7 has been reported to stimulate cell adhesion as well as motility in a manner similar to ECM proteins. EGFL7 has been shown to be primarily expressed by developing ECs but also by primordial germ cells and some central nervous system neurons. Interestingly, EGFL7 expression markedly decreases in ECs in postnatal life, but can be strongly up-regulated after various tissue injuries that lead to increased angiogenic responses.

Product Categories/Family for VE-Statin/EGFL-7 recombinant protein

Cytokines & Growth Factors

References

1. Schmidt MH et al, Nat Cell Biol 11:873, 2009 2. Nikolic et al, Blood 121:3041, 2013 3. Schmidt MH et al, Development 134: 2913-2923 (2007) 4. Socin F et al, EMBO Journal 22: 5700-5711 (2003) 5. Picuric S et al, Protein Expression and Purification 68: 1-6 (2009) 6. Caetano B et al, Protein Expression and Purification 46: 136-142 (2006) 7. Nichol D & Stuhlmann H, Blood 119:1345-1352 (2012)

NCBI and Uniprot Product Information

• NCBI GI #: 7705889
• NCBI GeneID: 51162
• NCBI Accession #: NP_057299.1
• NCBI GenBank Nucleotide #: NM_016215.4
• UniProt Accession #: Q9UHF1; Q5M7Y5; Q5VUD5; Q96EG0; B3KRP0
• Molecular Weight: 22,75 kDa
• NCBI Official Full Name: epidermal growth factor-like protein 7
• NCBI Official Synonym Full Names: EGF-like-domain, multiple 7
• NCBI Official Symbol: EGFL7
• NCBI Official Synonym Symbols: NEU1; ZNEU1; VE-STATIN; RP11-251M1.2
• NCBI Protein Information: epidermal growth factor-like protein 7; EGF-like protein 7; NOTCH4-like protein; vascular endothelial statin; multiple EGF-like domains protein 7; multiple epidermal growth factor-like domains protein 7
• UniProt Protein Name: Epidermal growth factor-like protein 7
• UniProt Gene Name: EGFL7
• UniProt Synonym Gene Names: MEGF7; EGF-like protein 7; Multiple EGF-like domains protein 7; VE-statin
• UniProt Entry Name: EGFL7_HUMAN

NCBI Description

This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Uniprot Description

Function: Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro

By similarity.

Subcellular location: Secreted

By similarity.

Sequence similarities: Contains 2 EGF-like domains.Contains 1 EMI domain.