Western Blot (WB)
(TBX4 Antibody (N-term) western blot analysis in A549,mouse NIH/3T3 cell line lysates (35ug/lane).This demonstrates the TBX4 antibody detected the TBX4 protein (arrow).)
Rabbit TBX4 Polyclonal Antibody | anti-TBX4 antibody
TBX4 Antibody (N-term)
Western Blot (WB)
(TBX4 Antibody (N-term) western blot analysis in A549,mouse NIH/3T3 cell line lysates (35ug/lane).This demonstrates the TBX4 antibody detected the TBX4 protein (arrow).)
Western Blot (WB)
(TBX4 Antibody (N-term) western blot analysis in A549,mouse NIH/3T3 cell line lysates (35ug/lane).This demonstrates the TBX4 antibody detected the TBX4 protein (arrow).)
family of genes that share a common DNA-binding domain, the T-box.
T-box genes encode transcription factors involved in the regulation
of developmental processes. This gene is the human homolog of mouse
Tbx4, which is closely linked to Tbx2 on mouse chromosome 11.
Similarly this gene, like TBX2, maps to human chromosome 17.
Expression studies in mouse and chicken show that Tbx4 is expressed
in developing hindlimb, but not in forelimb buds, suggesting a role
for this gene in regulating limb development and specification of
limb identity.
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]
Uniprot Description
TBX4: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX4 are the cause of small patella syndrome (SPS); also known as ischiopatellar dysplasia or Scott-Taor syndrome. SPS is an autosomal dominant skeletal dysplasia characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 17q21-q22
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; skeletal morphogenesis; multicellular organismal development; morphogenesis of an epithelium; angiogenesis; limb morphogenesis; embryonic limb morphogenesis; lung development
Disease: Small Patella Syndrome
Research Articles on TBX4
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Product Notes
The TBX4 tbx4 (Catalog #AAA9201892) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 103-129. The TBX4 Antibody (N-term) reacts with Human, mouse (Predicted Reactivity: Chicken, Rat, Xenopus) and may cross-react with other species as described in the data sheet. AAA Biotech's TBX4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the TBX4 tbx4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBX4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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