Typical Testing Data/Standard Curve (for reference only)
Human Endothelin-1 receptor ELISA Kit | EDNRA elisa kit
Human Endothelin-1 receptor ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Description
EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, GPCR; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q31.22
Cellular Component: cytosol; integral to plasma membrane; lipid raft; nuclear membrane; plasma membrane; T-tubule
Molecular Function: endothelin receptor activity; phosphoinositide phospholipase C activity; protein binding
Biological Process: adenylate cyclase activation; aging; artery smooth muscle contraction; cell proliferation; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); enteric nervous system development; fibroblast proliferation; G-protein coupled receptor protein signaling pathway; glomerular filtration; glucose transport; heart development; histamine secretion; in utero embryonic development; maternal process involved in parturition; negative regulation of apoptosis; negative regulation of cAMP biosynthetic process; neural crest cell development; patterning of blood vessels; penile erection; phospholipase C activation; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of odontogenesis; positive regulation of release of sequestered calcium ion into cytosol; protein kinase C activation; regulation of blood pressure; regulation of epithelial cell proliferation; respiratory gaseous exchange; response to hypoxia; response to lipopolysaccharide; response to morphine; Rho protein signal transduction; sensory perception of pain; signal transduction; smooth muscle cell proliferation; smooth muscle contraction; vasoconstriction
Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1
Research Articles on EDNRA
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Product Notes
The Human EDNRA ednra (Catalog #AAA289094) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA289094 ELISA Kit recognizes Human EDNRA. It is sometimes possible for the material contained within the vial of "Endothelin-1 receptor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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