Ectodysplasin-A (Eda) Recombinant Protein | Eda recombinant protein

Recombinant Mouse Ectodysplasin-A (Eda)

• Gene Names: Eda; Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ectodysplasin-A (Eda); Recombinant Mouse Ectodysplasin-A (Eda); Ectodysplasin-A; EDA protein homolog; Tabby proteinCleaved into the following 2 chains:; 1. Ectodysplasin-A; membrane form; 2. Ectodysplasin-A; secreted form; Eda recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 63-391
• Sequence: ELRSELRR ERGTESRLGG PGAPGTSGTL SSPGSLDPVG PITRHLGQPS FQQQPLEPGE DPLPPDSQDR HQMALLNFFF PDEKAYSEEE SRRVRRNKRS KSGEGADGPV KNKKKGKKAG PPGPNGPPGP PGPPGPQGPP GIPGIPGIPG TTVMGPPGPP GPPGPQGPPG LQGPSGAADK TGTRENQPAV VHLQGQGSAI QVKNDLSGGV LNDWSRITMN PKVFKLHPRS GELEVLVDGT YFIYSQVEVY YINFTDFASY EVVVDEKPFL QCTRSIETGK TNYNTCYTAG VCLLKARQKI AVKMVHADIS INMSKHTTFF GAIRLGEAPA S
• Sequence Length: 329

• Species: Mus musculus (Mouse)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 295789018
• NCBI GeneID: 13607
• NCBI Accession #: NP_001171408.1
• NCBI GenBank Nucleotide #: NM_001177937.1
• UniProt Accession #: O54693; O35705; Q9QWJ8; Q9QZ01; Q9QZ02; B7ZMT7
• Molecular Weight: 39,988 Da
• NCBI Official Full Name: ectodysplasin-A isoform 2
• NCBI Official Synonym Full Names: ectodysplasin-A
• NCBI Official Symbol: Eda
• NCBI Official Synonym Symbols: Ta; Ed1; HED; EDA1; XLHED; tabby; Eda-A1; Eda-A2
• NCBI Protein Information: ectodysplasin-A; EDA protein homolog
• UniProt Protein Name: Ectodysplasin-A
• Protein Family: Ectodysplasin
• UniProt Gene Name: Eda
• UniProt Synonym Gene Names: Ed1; Ta
• UniProt Entry Name: EDA_MOUSE

Uniprot Description

EDA: Seems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR. Defects in EDA are the cause of ectodermal dysplasia type 1 (ED1); also known as Christ-Siemens-Touraine syndrome or X-linked hypohidrotic ectodermal dysplasia (XLHED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ED1 is a disease characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. ED1 is the most common form of over 150 clinically distinct ectodermal dysplasias. Defects in EDA are the cause of tooth agenesis selective X-linked type 1 (STHAGX1). A form of selective tooth agenesis, a common anomaly characterized by the congenital absence of one or more teeth. Selective tooth agenesis without associated systemic disorders has sometimes been divided into 2 types: oligodontia, defined as agenesis of 6 or more permanent teeth, and hypodontia, defined as agenesis of less than 6 teeth. The number in both cases does not include absence of third molars (wisdom teeth). Belongs to the tumor necrosis factor family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Cellular Component: endoplasmic reticulum membrane; collagen; membrane; integral to plasma membrane; apical part of cell; integral to membrane; extracellular region; plasma membrane

Molecular Function: tumor necrosis factor receptor binding

Biological Process: skin development; positive regulation of I-kappaB kinase/NF-kappaB cascade; hair follicle development; pigmentation; cell-matrix adhesion; multicellular organismal development; immune response; gene expression; positive regulation of NF-kappaB import into nucleus; cell differentiation; odontogenesis of dentine-containing teeth